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:: Volume 3, Issue 1 (Spring 2013) ::
J Fasa Univ Med Sci 2013, 3(1): 49-55 Back to browse issues page
Antimicrobial and Antifungal Effects of Acid and Water-Soluble Chitosan Extracted from Indian Shrimp (Fenneropenaeus indicus) Shell
Ali Taheri 1, Amir Seyfan, Samira Jalalinezhad
1- , taheri@cmu.ac.ir
Abstract:   (28825 Views)

Background & Objective : Currently, efforts are underway to seek new and effective antimicrobial agents, and marine resources are potent candidates for this aim. The following study was conducted to investigate the efficacy of water-soluble and acid-soluble chitosan against some pathogenic organisms.

  

Materials & Method s: Inhibition zone of different concentrations (5, 7.5, and 10 mg/ml) of acid- soluble and water-soluble chitosan were examined for in vitro antibacterial activity against 4 kinds of hospital bacteria and penicillium sp. Results were compared with 4 standard antibiotics: streptomycin, gentamicin, tetracycline, and erythromycin. Furthermore, minimum inhibitory concentration and minimum lethal concentration were determined.

  

Results: Inhibition activity of acid-soluble chitosan (10%) showed the best result (p value < 0.05), whereas water-soluble chitosan exhibited the least antibacterial effects (p value < 0.05). Chitosan demonstrated maximum effect on V. cholera cerotype ogava , and the least effect was seen on E. coli (p value < 0.05). Acid-soluble chitosan had a more potent effect than the standard antibiotics. Also, acid-soluble chitosan (10%) and water-soluble chitosan showed maximum inhibitory effects on penicillium sp.

 

Conclusion: Chitosan showed maximum antibacterial effect against S. aureus, V. cholerae cerotype ogava, and water-soluble chitosan demonstrated good antifungal effects, revealing a statistically significant difference with common antibacterial and antifungal medicines.

Keywords: Chitosan, Antibacterial, Pathogens bacteria, Antifungal
Full-Text [PDF 509 kb]   (6906 Downloads)    
Type of Study: Research | Subject: Mycology
Received: 2013/06/2 | Accepted: 2013/09/14 | Published: 2013/09/14
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Taheri A, Seyfan A, Jalalinezhad S. Antimicrobial and Antifungal Effects of Acid and Water-Soluble Chitosan Extracted from Indian Shrimp (Fenneropenaeus indicus) Shell. J Fasa Univ Med Sci. 2013; 3 (1) :49-55
URL: http://journal.fums.ac.ir/article-1-219-en.html


Volume 3, Issue 1 (Spring 2013) Back to browse issues page
Journal of Fasa University of Medical Sciences
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