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:: Volume 3, Issue 2 (Summer 2013) ::
J Fasa Univ Med Sci 2013, 3(2): 174-178 Back to browse issues page
The association of interleukin-13 gene polymorphism withkala-azar patients
Elham Moazamian 1, Manoochehr Rasouli 2, Sadaf Asaei 2
1- Department of Microbiology, Islamic Azad University, Science and Research Branch, Fars, Iran. , elhammoazamian@gmail.com
2- Department of Immonology, Professor Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Abstract:   (22453 Views)
Background& Objective: Host resistance towards Leishmania infection is mediated by cellular immune responses leading to macrophage activation and parasite killing. According to the important role of IL-13 in the defense against visceral leishmaniasis (VL) and the known effect of the IL-13 gene polymorphisms on its production, the aim of this study was to investigate the probable relationship between IL-13 gene polymorphisms and susceptibility to VL.

Materials & Methods: The patient group included 52 patients who had suffered from VL infection and the control group consisted of 104 non-relative healthy people from the same endemic areas the patients were from (southern part of Fars Province). IL-13 (position -1512 A/C) gene polymorphism was determined by polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP).

Results: There was no significant association between the frequencies of IL-13 (-1512) alleles and genotypes in the patients with VL compared to the thenormal population.

Conclusion: This study indicated that the IL-13 (position -1512 A/C) genotypes cannot be considered as a genetic susceptibility factor for leishmaniasis.

 
Keywords: Interleukin-13, Genetic polymorphism, visceral leishmaniasis, Leishmania
Full-Text [PDF 728 kb]   (2500 Downloads)    
Type of Study: Research | Subject: Immunology
Received: 2013/09/15 | Accepted: 2013/10/6 | Published: 2013/10/6
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Moazamian E, Rasouli M, Asaei S. The association of interleukin-13 gene polymorphism withkala-azar patients. J Fasa Univ Med Sci. 2013; 3 (2) :174-178
URL: http://journal.fums.ac.ir/article-1-342-en.html


Volume 3, Issue 2 (Summer 2013) Back to browse issues page
Journal of Fasa University of Medical Sciences
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