Journal of Advanced Biomedical Sciences
JABS
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URL: http://jabs.fums.ac.ir/article-1-889-en.html
, Mina Hemmati2 , Mehdi Mahmodi1 , Ahmadreza Sayadi Anari3 , Mohammadreza Mirzaee1 , Alireza Khoshdel4 , Maryam Amiri5 , Fahimmeh MohammadainShahrbabaki1 , Mohammadreza Hajizade * 6
2- Department of Clinical Biochemical, Medical School, Birjand University of Medical Sciences, Birjand, Iran.
3- Social Determinants of Mental Health Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran,
4- Department of Clinical Biochemical, Medical School, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
5- Department of Clinical Biochemical, ShaahidBeheshti University of Medical Sciences, Tehran, Iran.
6- Molecular medicine research center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. , hajizadehus@yahoo.com
Background & Objectives: Industrial pollution including trace elements is the ability to exert many biological effects such as cancer and inflammatory diseases on humans. Therefore, in this study, some of the inflammation and cancer awareness factors such as P53 and IL6 and some blood indices are examined along with trace elements to which people are normally exposed.
Materials & Methods: The population includes 45 workers subjected to trace elements who are studied in comparison with the control group with some biochemical parameters such as WBC, RBC, and CRP. In addition, gene expressions of p53 and IL6 are measured by Real time PCR technique.
Results: The results show that the gene expressions of IL6 and P53 increases significantly (P –Value p53=0.00, IL6=0.0037). Furthermore, the number of red and white blood cells demonstrate a substantial upsurge. The level of liver enzymes of ALT and AST grows. Additionally, ALP reduces and CRP is negative in all the subjects. (P = 0.001).
Conclusion: The results confirm that industrial pollution is able to induce some changes in gene expressions of P53, IL6, and some blood parameters. It may create serious risks for people who will be exposed to pollution in the future.
Received: 2015/08/16 | Accepted: 2015/09/30 | Published: 2016/01/23
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This work is licensed under a Creative Commons — Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)