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:: Volume 7, Issue 4 (winter 2018) ::
J Fasa Univ Med Sci 2018, 7(4): 465-479 Back to browse issues page
robial and Antioxidant Activities and Determining Phenolic and Flavonoid Contents of the Extracts of Five Species from Different Families of the Medicinal Plants Grown in Sistan and Baluchestan Province
Omid Azizian Shermeh 1, Mojgan Taherizadeh 2, Moharam Valizadeh 3, Ali Qasemi 4
1- Medicinal and Ornamental Plant Research Center, University of Sistan and Baluchestan, Zahedan, Iran , omid_aziziyan@yahoo.com
2- Rural Water and Sewage Company of Sistan and Baluchestan, Zahedan, Iran
3- Department of Medicinal Plants, Faculty of Agriculture, University of Sistan and Baluchestan, Zahedan, Iran
4- Department of Biology, Faculty of Science, University of Sistan and Baluchestan, Zahedan, Iran
Abstract:   (1565 Views)

Background & Objectives: Traditionally use of the medicinal plants for treating of diseases. This present study is carried out to evaluate the antimicrobial and antioxidant activities and determination of total phenolic and flavonoid contents of three extracts (Methanolic, Ethanolic and Aqueous) of five different species of medicinal plants such as Withania somnifera L. Dunal., Salvia rhytidea Bent, Levisticum officinale L, Seidlitzia rosmarinus L., and Achillea wilhelmsii L.
Material & Methods: After preparing the extracts with maceration method, antioxidant activities were determined by two methods (DPPH and FRAP) and antimicrobial activities were estimated by Disk-Diffusion method against bacteria (Staphylococcus aureus, Bacillus cereus, Escherichia coli and fungi (Aspergillus niger and Candida albicans) and phenolic and flavonoid contents were determined by Folin-Ciocaltiu, Aluminum Chloride colorimetric.
Results: The results showed that, the methanolic extract of W. somnifera had maximum total phenolic (41.45±4.64 mgGAE/gExtract) and flavonoid contents (35.21±2.54 mgQUE/gExtract) and antioxidant activity, (IC50=8.12±1.36µg/ml, 58.19±1.68 mM Fe2+/mgExtract) and antimicrobial activity against Staphylococcus aureus and Candida albicans with the diameter of inhibition zone (29±1.06 and (27±1.00 mm) respectively. In contrast, the aqueous extract of L. officinale had minimum value of total phenolic (17.12±1.93 mgGAE/gExtract) and flavonoid contents (12.61±2.06 mgQUE/gExtract) and antioxidant activity (IC50=121.43±3.36µg/ml, 13.74±2.52 mM Fe2+/mgExtract) and antimicrobial activity against Bacillus cereus and Aspergillus niger with the diameter of inhibition zone (4±0.57 and 5±1.00 mm) respectively.
Conclusion: Overall, based on the results, the studied plants can be a good candidate for the treatment of diseases caused by oxidative stress, and diseases are caused by pathogenic microbes.
 
 

Keywords: Antimicrobial activity, Antioxidant activity, Phenolic content, Flavonoid content, Sistan and Baluchestan province
Full-Text [PDF 510 kb]   (486 Downloads)    
Type of Study: Research | Subject: Pharmaceutical Plants
Received: 2017/03/22 | Accepted: 2017/07/20 | Published: 2017/12/31
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Azizian Shermeh O, Taherizadeh M, Valizadeh M, Qasemi A. robial and Antioxidant Activities and Determining Phenolic and Flavonoid Contents of the Extracts of Five Species from Different Families of the Medicinal Plants Grown in Sistan and Baluchestan Province. J Fasa Univ Med Sci. 2018; 7 (4) :465-479
URL: http://journal.fums.ac.ir/article-1-1387-en.html


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