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:: Volume 8, Issue 1 (Spring 2018) ::
J Fasa Univ Med Sci 2018, 8(1): 594-600 Back to browse issues page
Association of UCP3 (uncoupling protein 3) gene -55C/T polymorphism and obesity in a juvenile population of Iran
Hossein Mohamad Rezaii 1 , Mohsen Kalantari 2 , Sanaz Mahmazi 3
1- Genetic Group, Islamic Azad University, Zanjan Branch, Zanjan, Iran
2- Genetic Group, Department of cellular and molecular biology, Islamic Azad University, Zanjan Branch, Zanjan, Iran
3- Genetic Group, Islamic Azad University, Zanjan Branch, Zanjan, Iran , sanaz.mahmazi@iauz.ac.ir
Abstract:   (1179 Views)

Background & Objective: UCP3 is a member of uncoupling proteins which plays an important role in energy homeostasis and it might be important in obesity. C-55T (rs1800849) polymorphism in promoter of UCP3 can affect the expression level of UCP3. The aim of this study was to analyze the association
of UCP3 C-55T polymorphism and obesity in a juvenile population of Iran.
Material & Methods: peripheral blood sample from 120 obese and 120 normal university students were collected for DNA extraction. Genotyping of C-55T polymorphism in the UCP3 gene was performed by PCR-RFLP method. Chi-square test was applied to analyze the data at P<0.05 significance level.
Results: The variant T allele was significantly associated with the obesity risk. The frequency of T allele was 72% in Obese group compared to 40% in normal subjects (P= 0.000, OR=3.8 CI 95% 2.1 – 6.9).
Conclusion: The UCP3 C-55T polymorphism was associated with higher BMI and can be regarded as a risk factor for the development of obesity.
 
 

Keywords: obesity, UCP3 gene, polymorphism, PCR-RFLP
Full-Text [PDF 815 kb]   (272 Downloads)    
Type of Study: Research | Subject: Genetics
Received: 2016/09/28 | Accepted: 2017/05/7 | Published: 2018/04/22
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Mohamad Rezaii H, Kalantari M, Mahmazi S. Association of UCP3 (uncoupling protein 3) gene -55C/T polymorphism and obesity in a juvenile population of Iran. J Fasa Univ Med Sci. 2018; 8 (1) :594-600
URL: http://journal.fums.ac.ir/article-1-1089-en.html


Volume 8, Issue 1 (Spring 2018) Back to browse issues page
Journal of Fasa University of Medical Sciences
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