[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Submit :: Contact Us ::
:: Volume 2, Issue 3 (Autumn 2012) ::
J Fasa Univ Med Sci 2012, 2(3): 174-180 Back to browse issues page
The Effect of Hydroalcoholic Extracts of Prangos Ferulacea on Blood Factors of Kidney and Liver Functions in Diabetic Male Wistar Rats
Tahereh Zare, Mokhtar Mokhtari, Jamshid Mohammadi 1
1- , J_mohammadi2005@yahoo.com
Abstract:   (24204 Views)

Background and Objective: Diabetes mellitus is a chronic disease recognized by a reduction in insulin secretion due to the malfunction of β cells in the pancreas or an increase in the cell's resistance to insulin. Prangos Ferulacea has been known as an analgesic and anti-inflammatory herb in the general population. The aim of the present study was to evaluate the effect of the hydroalcoholic extracts of Prangos Ferulacea on the blood factors of kidney and liver functions in diabetes induced by streptozotocin in Wistar rats.

Materials and Methods: In this experimental study, six groups of animals were selected. Three groups out of six were administered with intra peritoneal injection of streptozotocin to induce diabetes. Group I was fed a normal diet. Group II and III of the animals received 300 and 500 mg/kg/day Prangos Ferulacea extract. Group IV received distilled water (diabetic control), and the animals of groups V and VI were treated with Prangos Ferulacea extract 300 and 500 mg/kg body weight, respectively, for three weeks. Blood glucose, ALT, AST, ALP, creatinine, albumin, urea and BUN were measured in all the animals. The collected data were analyzed using SPSS software via the one-way ANOVA.

Results: Treatment with the Prangos Ferulacea extract resulted in a significant decrease in blood glucose, ALT, AST and creatinine but no significant decrease in ALP, albumin, urea, and BUN levels. Conclusion: The results of this study showed that hydroalcoholic extracts of Prangos Ferulacea had antidiabetic effects and consequently might alleviate the liver and kidney damage caused by streptozotocin-induced diabetes mellitus.

Keywords: Diabetes mellitus, Prangos ferulacea, glucose, Blood biochemical factors
Full-Text [PDF 1473 kb]   (4854 Downloads)    
Type of Study: Research | Subject: Physiology
Received: 2013/02/19 | Accepted: 2013/09/14 | Published: 2013/09/14
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

zare T, Mokhtari M, Mohammadi J. The Effect of Hydroalcoholic Extracts of Prangos Ferulacea on Blood Factors of Kidney and Liver Functions in Diabetic Male Wistar Rats. J Fasa Univ Med Sci. 2012; 2 (3) :174-180
URL: http://journal.fums.ac.ir/article-1-111-en.html


Volume 2, Issue 3 (Autumn 2012) Back to browse issues page
Journal of Fasa University of Medical Sciences
Persian site map - English site map - Created in 0.18 seconds with 32 queries by YEKTAWEB 4006