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:: Volume 7, Issue 4 (winter 2018) ::
J Fasa Univ Med Sci 2018, 7(4): 438-446 Back to browse issues page
Determining the relationship between cagA+ Helicobacter Pylori infection and microalbuminuria in type2 diabetic rats
Mansoureh Ahrarifar 1, Majid BaseriSalehi 2
1- Department of Microbiology, College of Science, Islamic Azad University of Kazeroun, Kazeroun, Iran
2- Department of Microbiology, College of Science, Islamic Azad University of Kazeroun, Kazeroun, Iran , Majidbaseri@hotmail.com
Abstract:   (1376 Views)

Background & Objectives: Microalbuminuria is a metabolic disease, which is related to the development of diabetic nephropathy. There are several reports indicating high frequency of the occurrence of Helicobacter pylori infection in diabetic patients. It means that probably, there is a relationship between cagA positive Helicobacter pylori and microalbuminuria in diabetic patients. Hence, the present study was conducted to investigate the relationship between cagA positive Helicobacter pylori infection and microalbuminuria in the patients with type 2 diabetes.
Material & Methods: Totally, 76 blood and urine samples were collected from patients with type 2 diabetes. The blood samples were used to assess Glycoside Hemoglobin, Fasting Blood Sugar, two-hour postprandial Glucose, Anti-HpIgG and Anti-HpIgM. Molecular method was carried out for identification and helicobacter pylori positive samples were tested for the detection of cagA gene. Finally, Chi-Square test and Fisher technique were applied to analyze the data.
Results: The results obtained from this study indicated that Helicobacter pylori was isolated from 28 patients (36.84%) from which, 21 patients (75%) were afflicted with microalbuminuria and 8 samples (25%) were cagA genes positive. The results indicated that there was no statistically significant difference between cagA gene of Helicobacter pylori and microalbuminuria in patients with type 2 diabetes.
Conclusion: the findings showed that there was no significant correlation between cagA gene positive Helicobacter pylori infection, and microalbuminuria in the patients with type 2 diabetes.
 

Keywords: Helicobacterpylori, cagA gene, microalbuminuria
Full-Text [PDF 421 kb]   (249 Downloads)    
Type of Study: Research | Subject: Microbiology
Received: 2016/11/4 | Accepted: 2017/07/4 | Published: 2018/01/1
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Ahrarifar M, BaseriSalehi M. Determining the relationship between cagA+ Helicobacter Pylori infection and microalbuminuria in type2 diabetic rats. J Fasa Univ Med Sci. 2018; 7 (4) :438-446
URL: http://journal.fums.ac.ir/article-1-1160-en.html


Volume 7, Issue 4 (winter 2018) Back to browse issues page
Journal of Fasa University of Medical Sciences
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