:: Volume 7, Issue 2 (Summer 2017) ::
J Fasa Univ Med Sci 2017, 7(2): 217-222 Back to browse issues page
Investigating the association of rs1862513 genetic variant in resistin gene with susceptibility to breast cancer
Leila Kohan
1- Department of biology, Arsanjan Branch, Islamic Azad University, Arsanjan, Iran 2- Young Researcher and Elite club, Arsanjan Branch, Islamic Azad University, Arsanjan, Iran , leila_kohan@yahoo.com
Abstract:   (944 Views)

Background & objective: Resistin is a unique hormone secreted from adipocytes. Recent data indicated that resistin levels have been associated with inflammatory markers; Due to the fact that chronic inflammation plays a role in breast cancer, it seems that resistin may present a molecular link between inflammation and breast carcinogenesis. The aim of this study was to investigate the association of rs1862513 promoter resistin gene variant with breast cancer risk.
Material & Methods: For the purpose of this case-control study, 150 breast cancer and 150 healthy control blood samples were collected. After DNA extraction, genotype determination was performed by PCR-RFLP method. Statistical analysis was done using logistic regression model.
Results: The case and control groups were in Hardy-Weinberg equilibrium. The subjects with GG genotype had increased risk of breast cancer compared to those with CC genotype (OR: 1.9, 95% CI: 1-3.7, P: 0.04). Also, the G allele indicated a positive association with breast cancer susceptibility (OR: 1.4, 95% CI: 1-1.98, P: 0.03).
Conclusion: Results of this study showed possible association of resistin rs1862513 gene variant with breast cancer risk in Iranian women.

Keywords: Resistin, Breast cancer, Promoter, Genetic variant
Full-Text [PDF 1081 kb]   (268 Downloads)    
Type of Study: Research | Subject: Genetics
Received: 2017/01/7 | Accepted: 2017/04/17 | Published: 2017/09/3

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Volume 7, Issue 2 (Summer 2017) Back to browse issues page