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:: Volume 8, Issue 1 (Spring 2018) ::
J Fasa Univ Med Sci 2018, 8(1): 601-607 Back to browse issues page
The Effects of Levels of Oral Di-(2-ethylhexyl) Phthalate on Glycemic Response in Mice
Behzad Najmi kargan 1, Ali Kargari Rezapour 2 , Rasoul Sharifi 3
1- Department of Biologhy, Faculty of Basic Sciences, Islamic Azad University of Ahar, Ahar, Iran , behzad.najmi.bn@gmail.com
2- Department of Clinical pathology, Faculty of Veterinary Medicine, Islamic Azad University of Tabriz, Tabriz, Iran
3- Department of Biologhy, Faculty of Basic Sciences, Islamic Azad University of Ahar, Ahar, Iran
Abstract:   (515 Views)

Background & Objective: Humans are widely exposed to di-(2-ethylhexyl) phthalate that it can rise obesity and type 2 diabetes epidemics. The object of this study was to investigate the effects of oral di-(2-ethylhexyl) phthalate (DEHP) at minimum and maximum levels on glycemic response in mice.
Material & Methods: An interventional study with 15 adult male mice was designed. Mice were randomly assigned to 3 equal groups: control, 1x phthalate (dose of 250 mg/kg/day), 2x phthalate (dose of 500 mg/kg/day) and treated for a period of 8 weeks. At the end of the seventh week study all mice were tested by oral glucose tolerance test and area under curve (AUC) was calculated for each sample. In the end, fasting blood samples were used to measure the variables (Glucose, Insulin, HOMA_IR, Quicki of serum and HbA1C of total blood). The data were analyzed by ANOVA and Duncan tests. The significant difference in the data was considered P >0.01.
Results: Di-(2-ethylhexyl) phthalate at low dose (250 mg/kg) showed significant increase in serum glucose and insulin resistance levels and also quicki levels decreased significantly compared to other groups (P <0.01). This study showed no significant changes in insulin serum, glycated hemoglobin (HbA1c) of total blood and area under the curve in glucose tolerance test (P >0.01).
Conclusion: In the present study, it showed di-(2-ethylhexyl) phthalate at low dose (250 mg/kg) impaired blood sugar control systems and this can lead in pre-diabetes.
 
 

Keywords: Di-(2-ethylhexyl) phthalate, Glycemic response, Mice
Full-Text [PDF 896 kb]   (151 Downloads)    
Type of Study: Research | Subject: Biochemistry
Received: 2016/10/19 | Accepted: 2017/05/3 | Published: 2018/04/22
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Najmi kargan B, Kargari Rezapour A, Sharifi R. The Effects of Levels of Oral Di-(2-ethylhexyl) Phthalate on Glycemic Response in Mice. J Fasa Univ Med Sci. 2018; 8 (1) :601-607
URL: http://journal.fums.ac.ir/article-1-1175-en.html


Volume 8, Issue 1 (Spring 2018) Back to browse issues page
Journal of Fasa University of Medical Sciences
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