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:: Volume 7, Issue 3 ( Autumn 2017) ::
J Fasa Univ Med Sci 2017, 7(3): 297-306 Back to browse issues page
The Dual Role of Inflammatory Responses following Vibrio cholerae Infection in Cholerae pathogenesis
Alireza Moulazade 1, Sara Soudi 2, Bita Bakhshi 3
1- Department of Immunology, Faculty of medical sciences, Tarbiat Modares University, Tehran, Iran
2- Department of Immunology, Faculty of medical sciences, Tarbiat Modares University, Tehran, Iran , soudi@modares.ac.ir
3- Department of Bacteriology, Faculty of medical sciences, Tarbiat Modares University, Tehran, Iran
Abstract:   (801 Views)
Cholera is an acute and dangerous intestinal diarrhea that leads to death if hypovolemic shock occures. Vibrio cholera, as a causative agent of cholera, is a noninvasive enteric gram-negative bacteria which exerts its pathological effects by producing cholerae toxin (CT). The first time, the acute inflammatory responses of Cholerae was considered when the development of laboratory techniques in the last years demonstrated that CT can induce lipid mediators synthesis like prostaglandin E2, F2 and leukotrienes and recruit neutrophils, mast cells, macrophages and other immune cells. The recruited cells respond to infection by lactoferrin and myeloperoxidase secretion in the excretory liquid and production of inflammatory cytokines like, TNF-α, IL-1 and IL-6. On the one hand, the formed inflammatory responses, stimulate innate and adaptive immune system and produce antibodies against Vibrio cholerae, but  on the other hand, it enhances the excretion of water and salts from the gastrointestinal tract epithelial cells and induces apoptosis and loss of defensive function of epithelial barrier. Although the epithelial cell shedding and excretion of infected fluids from the intestinal tract is the body’s natural defensive mechanism to remove bacteria, but in the case of the failure in bacteria reduction and lost fluid compensation by serum therapy, the disease will lead to death. Therfore the use of antibiotics and anti-inflammatory drugs will be effective besides serum therapy to reduce the number of baceria and fluid loss from the body and repair the epithelial barrier.
Keywords: Vibrio cholerae, Cholerae Toxin, inflammatory responses.
Full-Text [PDF 1201 kb]   (163 Downloads)    
Type of Study: Review | Subject: Immunology
Received: 2017/01/15 | Accepted: 2017/04/14 | Published: 2017/12/2
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Moulazade A, Soudi S, Bakhshi B. The Dual Role of Inflammatory Responses following Vibrio cholerae Infection in Cholerae pathogenesis. J Fasa Univ Med Sci. 2017; 7 (3) :297-306
URL: http://journal.fums.ac.ir/article-1-1255-en.html


Volume 7, Issue 3 ( Autumn 2017) Back to browse issues page
Journal of Fasa University of Medical Sciences
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