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:: Volume 7, Number 1 (Spring 2017) ::
J Fasa Univ Med Sci 2017, 7(1): 141-149 Back to browse issues page
The antidepressant-like effect of Mentha spicata essential oil in animal models of depression in male mice
Dr Behnam Jedi-Behnia1, Dr Saeid Abbasi Maleki 2, Dr Elahe Mousavi3
1- Pharm.D Pharmaceutical
2- tant Professor Urmia Branch,Islamic Azad University , s.abbasi@iaurmia.ac.ir
3- Assistant Professor Pharmaceutical Science Branch, Islamic Azad University, Tehran
Abstract:   (795 Views)

Background & Objective: Previous researches have revealed analgesic and sedative properties of Mentha spicata (MS). The aim of present study was to evaluate the antidepressant effects of MS essential oil in forced swim test (FST) and tail suspension test (TST) in male mice.

Materials & Methods: In this experimental study, 84 male mice were randomly divided into 14 groups of 6: Negative control groups received normal saline (10 ml/kg,i.p.), positive control groups received fluoxetine (20mg/kg, i.p.) and imipramine (30mg/kg) and treatment groups received MS essential oil (30, 60,120 and 240 mg/kg i.p.). In FST, immobility time, swimming time and climbing time and immobility time in TST were recorded in six minutes.

Results: Findings indicated that essential oil at doses of 120 and 240 mg/kg, fluoxetine and imipramine reduced immobility time compared to control group in FST and TST (p<0.001). Also, this essential oil and fluoxetine increased swimming time (p<0.001) without significant change of climbing time (p>0.05). In contrast, imipramine increased climbing time without any significant change in swimming time (p>0.05).

Conclusion: Based on the findings of the present study, MS essential oil has antidepressant-like activity similar to fluoxetine and probably their compounds (especially carvone) with serotonergic mechanism induced their effect. However, further studies are needed to determine the precise mechanism of its action.

Keywords: Mentha spicata, Forced swim test, Tail suspension test, Serotonergic system, Mice
Full-Text [PDF 1353 kb]   (185 Downloads)    
Type of Study: Research | Subject: Pharmacology
Received: 2016/11/27 | Accepted: 2017/04/5 | Published: 2017/06/7
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Jedi-Behnia B, Abbasi Maleki S, Mousavi E. The antidepressant-like effect of Mentha spicata essential oil in animal models of depression in male mice. J Fasa Univ Med Sci. 2017; 7 (1) :141-149
URL: http://journal.fums.ac.ir/article-1-1292-en.html
Volume 7, Number 1 (Spring 2017) Back to browse issues page
Journal of Fasa University of Medical Sciences
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