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:: Volume 8, Issue 1 (Spring 2018) ::
J Fasa Univ Med Sci 2018, 8(1): 666-673 Back to browse issues page
Investigating the effect of intraperitoneal administration of zinc oxide nanoparticles on the model of postpartum depression in adult female mice
Sahar Fadaei 1 , Saeid Valipour Chahardahcharic 2, Hosein Sazgar 1
1- Department of Biology, Faculty of Sciences, Shahre Kord Branch, Islamic Azad University, Shahre Kord, Iran
2- Assistant Professor Department of Biology, Faculty of Sciences, Izeh Branch, Islamic Azad University, Izeh, Iran , valipoursaeed@gmail.com
Abstract:   (370 Views)

Background & Objective: Postpartum depression appears to be a harmful condition affecting mothers and their babies negatively. Regarding their side effects, the tendency to use antidepressants has especially fallen in nursing mothers. Considering the effect of zinc on mood, this study was conducted to determine the efficacy of zinc oxide nanoparticles on postpartum depression in female mice.
Material & Methods: In this experimental study, the adult female mice of NMARI breed (25-30gr) were divided into six groups respectively (n=8): 1) Control 2) Depressed group 3, 4, 5) Depressed groups treated with a dose of zinc oxide nanoparticles including (5, 10 and 20 mg/kg) 6) Depressed groups treated for 8 days with a dose of 5 mg/kg zinc oxide nanoparticles.
First, the studied animals were depressed by intraperitoneal injection of 5mg/kg progesterone for 5 days. The control group received no drug or solvent. The assessment of depression rate on the eighth day after the start of administration of progesterone was conducted by forced swim test.
Results: The zinc oxide nanoparticles at doses 10 mg/kg (P< 0.01) and 20 mg/kg (P< 0.05) and also at 5 mg/kg dose for 8 days (P< 0.01) led to a significant decrease in immobilization time in depressed mice.
Conclusion: Administration of progesterone induces depression, and thus, increases the period of immobilization of mice. The zinc oxide nanoparticles reduced the symptom of postpartum depression in forced swim test. The findings can be used to show the effects of zinc oxide nanoparticles in the reduction of postpartum depression.
 

Keywords: Postpartum depression, Zinc oxide nanoparticles, Progesterone, Mice
Full-Text [PDF 913 kb]   (117 Downloads)    
Type of Study: Research | Subject: Physiology
Received: 2017/05/29 | Accepted: 2017/12/17 | Published: 2018/05/30
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Fadaei S, Valipour Chahardahcharic S, Sazgar H. Investigating the effect of intraperitoneal administration of zinc oxide nanoparticles on the model of postpartum depression in adult female mice. J Fasa Univ Med Sci. 2018; 8 (1) :666-673
URL: http://journal.fums.ac.ir/article-1-1463-en.html


Volume 8, Issue 1 (Spring 2018) Back to browse issues page
Journal of Fasa University of Medical Sciences
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