:: Volume 8, Issue 3 ( Autumn 2018) ::
J Fasa Univ Med Sci 2018, 8(3): 862-869 Back to browse issues page
Effect of Hydro-alcoholic Extract of Rosemary in Comparison with Alprazolam on Learning under Stress Conditions in Rats
Mehrdad Modaresi 1, Masoume Amoorizi
1- , mehrdad_modaresi@hotmail.com
Abstract:   (1528 Views)

Background & Objective: Many anti stress drugs have a lot of side effects on learning. The aim of this study was to compare the effect of Rosemary plant and Alprazolam on learning under stress conditions in laboratory mice.
Materials & Methods: In this experimental study, 60 adult female rats were used. In order to investigate the learning capacity under stress conditions, the rats were divided into 6 groups of control, stress, alprazolam and the three experimental groups that received the hydro-alcoholic extract of rosemary plants at doses of 50, 100 and 200. In all of the samples (except the control group) 30 minutes after injection, the mice were placed in a dark box for 50 minutes for stress. Subsequently, observational behaviors of the rats were recorded by using mouse maze. The results were analyzed using SPSS software.
Results: The results showed that rosemary hydro alcoholic extract at 100 and 200 mg/kg compared to the stress and alprazolam group significantly decreased the time to reach the target box in the Maze form, which indicates a reduction on effect of stress on the learning, while the number of errors in selecting the target box (reaching the target) at a dose of 200 mg/kg shows a significant decrease with the stress and drug group.
Conclusion: According to the results, effective compounds in rosemary extract in two doses of 100 and 200 mg/kg can increase the learning in these conditions with the effect of reducing stress.

Keywords: Rosemary, Learning, Stress, Alprazolam, T-shaped maze, Mice
Full-Text [PDF 736 kb]   (286 Downloads)    
Type of Study: Research | Subject: Physiology
Received: 2018/01/14 | Accepted: 2018/08/4 | Published: 2018/12/22

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Volume 8, Issue 3 ( Autumn 2018) Back to browse issues page