Journal of Advanced Biomedical Sciences
JABS
Tue, Apr 23, 2024
[Archive]
Volume 9, Issue 3 (9-2019)
JABS 2019, 9(3): 1621-1631 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
asgarirad H, farmoudeh A, rezaeiroshan A, rajaei M. Preparation and Characterization of Paracetamol Solid Dispersions Using Opened Ring PVP and PEG 4000. JABS 2019; 9 (3) :1621-1631
URL: http://jabs.fums.ac.ir/article-1-1944-en.html
URL: http://jabs.fums.ac.ir/article-1-1944-en.html
Preparation and Characterization of Paracetamol Solid Dispersions Using Opened Ring PVP and PEG 4000
1- Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
2- Pharmaceutical Sciences Research Centre, Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran , farmoudeh.af@gmail.com
3- Pharmaceutical Sciences Research Centre, Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
2- Pharmaceutical Sciences Research Centre, Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran , farmoudeh.af@gmail.com
3- Pharmaceutical Sciences Research Centre, Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
Abstract: (2921 Views)
Background & Objective: Solid dispersions (SDs) have been traditionally used as an effective method for improving the dissolution properties and bioavailability of poorly water-soluble drugs. The aim of this study was to improve the solubility and dissolution rate of paracetamol by SD technique.
Materials & methods: The prepared SDs were evaluated by saturation solubility test, In-vitro drug release test, differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM).
Results: The prepared SDs exhibited a statistically significant increase in the solubility of paracetamol compared to that of the free drug (p < 0.05). After 15 min SD tablets had an enhanced cumulative drug release compared to tablets of the free drug (p < 0.05). FTIR study revealed that paracetamol was stable in polymeric dispersions. DSC and SEM microscopy showed that the drugs crystallinity was decreased during the preparation process (amorphous crystal formation).
Conclusion: The FTIR spectroscopic test revealed the presence of intermolecular hydrogen bonding between paracetamol and the polymers in the SDs, which could increase the aqueous solubility of the drug. The DSC analysis indicated that the drug was in the amorphous state when dispersed in the polymers. Dissolution studies indicated that the dissolution rates were markedly increased in the SDs compared with those of paracetamol alone, and Better results were obtained with PVP K25.
Materials & methods: The prepared SDs were evaluated by saturation solubility test, In-vitro drug release test, differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM).
Results: The prepared SDs exhibited a statistically significant increase in the solubility of paracetamol compared to that of the free drug (p < 0.05). After 15 min SD tablets had an enhanced cumulative drug release compared to tablets of the free drug (p < 0.05). FTIR study revealed that paracetamol was stable in polymeric dispersions. DSC and SEM microscopy showed that the drugs crystallinity was decreased during the preparation process (amorphous crystal formation).
Conclusion: The FTIR spectroscopic test revealed the presence of intermolecular hydrogen bonding between paracetamol and the polymers in the SDs, which could increase the aqueous solubility of the drug. The DSC analysis indicated that the drug was in the amorphous state when dispersed in the polymers. Dissolution studies indicated that the dissolution rates were markedly increased in the SDs compared with those of paracetamol alone, and Better results were obtained with PVP K25.
Type of Study: Research |
Subject:
Pharmacology
Received: 2019/01/27 | Accepted: 2019/07/14 | Published: 2019/12/10
Received: 2019/01/27 | Accepted: 2019/07/14 | Published: 2019/12/10
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
This work is licensed under a Creative Commons — Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)