:: Volume 3, Issue 1 (Spring 2013) ::
J Fasa Univ Med Sci 2013, 3(1): 69-74 Back to browse issues page
Effect of Camphor on Pituitary-Gonadal Hormonal Axis and Oogenesis in Adult Female Rats
Habibollah Johari 1, Amir Ashkan Mahjoor, Siyamak Fallahi, Hossein Kargar Jahromi, Maryam Abedini, Mohammad Ali Poor Danesh, Zahra Zamani
1- , hjowhary@yahoo.co.uk
Abstract:   (27249 Views)

Background & Objective: Camphor stimulates the nervous system and the circulatory system, reduces lactation, and prevents conception and embryo embedding. We investigated the effects of camphor on the pituitary-gonadal hormonal axis and concentration of steroidal hormones.

  

Materials & Methods: The parameters investigated were concentrations of LH, FSH, estrogen, progesterone, and testosterone. Forty adult female rats at a mean weight of 180 ± 20 grams were divided into five groups. Camphor solution was prepared in olive oil at 25, 50, and 100 mg/kg doses, and 0.2 cc injections were done intraperitoneally every day for 2 weeks. The control group received no injection. The sham group received olive oil (as solvent of camphor) and treatment groups of 1, 2, and 3 received doses of 25, 50, and 100 mg/kg. The treatment groups were sacrificed one day after the last injection, and their hearts were dissected and blood samples were obtained. The concentrations of the hormones were measured by the ELISA test, and the results were evaluated via the t-test, ANOVA, and Duncan.

  

Results: The results showed a significant decrease in the concentrations of testosterone and progesterone (p value < 0.05) and a significant increase in the concentrations of LH and FSH (p value <0.05).

 

Conclusion: Camphor augmented oogenesis via effecting a rise in the concentrations of LH and FSH in our rats.

Keywords: Camphor, Oogenesis, LH, FSH, Testosterone, Rat
Full-Text [PDF 1237 kb]   (3590 Downloads)    
Type of Study: Research | Subject: Physiology
Received: 2012/10/29 | Accepted: 2013/03/13 | Published: 2013/09/14


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Volume 3, Issue 1 (Spring 2013) Back to browse issues page