:: Volume 5, Issue 1 (Spring 2015) ::
J Fasa Univ Med Sci 2015, 5(1): 120-133 Back to browse issues page
Evaluation of Serum Vaspin and Chemerin Levels in Type 2 Diabetic and Treated with Anti Diabetic Drugs Metformin and Acarbose in Rats
Seyed Mohammad Ali Ghaffari 1, Mohammad taghi Mansouri2, Mohammad Hossein Haghighizadeh3, Elham Rafie4
1- Department of Biochemistry and Cellular and Molecular Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. , ghaffarima@yahoo.com
2- Department of Pharmacology, Faculty of Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
3- Department of Statistics, Faculty of Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
4- Medical and Molecular Research Center, Arak University of Medical Sciences, Arak, Iran.
Abstract:   (10382 Views)

 

Background & Objective: The serum levels of adipose tissue hormons, Vaspin and Chemerin, alter in some disorder conditions such as diabetes. The aim of this study is to investigate the effect of two anti-diabetic drugs (Metformin and Acarbose) and their combination on serum concentration of Vaspin and Chemerin in type 2 diabetic rats.

 

Materials & Methods: 30 male, wistar rats are randomly divided into 5 groups, while 4 groups are suffered from type 2 diabetes, and 3 groups of these diabetics are cured using metformin, acarbose, and combination of both, respectively, during 6 weeks. Body weight, fasting glucose, glycated hemoglobin, lipid profile, and serum’s vaspin and chemerin are being examined. Statistic data are analyzed using SPSS software. Results report by mean ± standard deviation, and statistic difference considers significant by P˂0.05.

 

Results: Findings of this study show a significant decrease for vaspin (P=0.001) and a significant increase for chemerin levels (P=0.004) in diabetic control group compared with normal control group. Treatment of all groups show a significant increase in serum levels of vaspin (P=0.001) while treatment by metformin results in a significant decrease in chemerin level in this group (P=0.036). In this study, fasting blood glucose, glycated hemoglobin, and lipid profile in treated group with both of drugs show decrease that is more significant.

 

Conclusion: Probably metformin and acarbose through increase of serum level of vaspin leads to reduction of insulin resistance.

  

Keywords: Acarbose, Metformin, Type 2 Diabetes, Rat, Vaspin, Chemerin
Full-Text [PDF 1500 kb]   (1978 Downloads)    
Type of Study: Research | Subject: Biochemistry
Received: 2014/11/10 | Accepted: 2015/02/25 | Published: 2015/06/22


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Volume 5, Issue 1 (Spring 2015) Back to browse issues page