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:: Volume 7, Number 1 (Spring 2017) ::
J Fasa Univ Med Sci 2017, 7(1): 12-20 Back to browse issues page
Effects of inhalation of oil-paint fumes of construction industry on serum level of FSH, LH, estradiol and 17-alpha- hydroxyprogesterone in female rats
Maryam Siavashi 1, Rahim Ahmadi2, behrooz khakpoor3
1- Department of Biology, Islamic Azad University, Hamedan Branch, Hamedan, Iran , msiavashi80@yahoo.com
2- Department of Biology, Islamic Azad University, Hamedan Branch, Hamedan, Iran
3- School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
Abstract:   (798 Views)

Background & Objective: Studies have shown that exposure to oil paint and chemical vapor emissions is followed by physiological disorders. The aim of this study was to determine the effects of inhalation of oil-paint fumes of construction industry on serum level of FSH, LH, Estradiol and 17-Alpha- Hydroxyprogesterone in female rats.

Material & Methods: In this experimental study, 15 female Wistar rats were randomly divided into control and groups exposed to paint vapor emissions for 1 and 8 h/day. After 10 weeks, blood samples were prepared using cardiac puncture method and after serum preparation, level of FSH, LH, estradiol and 17-alpha- hydroxyprogesterone was measured by radioimmunoassay method and finally data were analyzed using one-way ANOVA with a significance level of P<0.05

Results: The mean serum levels of FSH and LH in experimental groups which inhaled oil-paint fumes for 1 and 8 h/day increased significantly (P<0.001 and P<0.05) and the mean serum levels of estradiol and 17-alpha- hydroxyprogesterone in both groups had a significant reduction (P<0.001 and P<0.01) compared to the control group.

Conclusion: Results show that exposure to oil paint fumes, due to their components such as heavy metals and paint solvent, by some possible mechanisms such as free radical formation, and oxidative stress induction could disrupt the secretion of FSH, LH, Estradiol and 17-Alpha- Hydroxyprogesterone hormones

Keywords: Oil paint-fumes, LH, FSH, Estradiol, 17-Alpha- Hydroxyprogesterone, Rat
Full-Text [PDF 1334 kb]   (190 Downloads)    
Type of Study: Research | Subject: Physiology
Received: 2016/06/9 | Accepted: 2016/11/7 | Published: 2017/06/6
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Siavashi M, Ahmadi R, khakpoor B. Effects of inhalation of oil-paint fumes of construction industry on serum level of FSH, LH, estradiol and 17-alpha- hydroxyprogesterone in female rats . J Fasa Univ Med Sci. 2017; 7 (1) :12-20
URL: http://journal.fums.ac.ir/article-1-887-en.html
Volume 7, Number 1 (Spring 2017) Back to browse issues page
Journal of Fasa University of Medical Sciences
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