Journal of Advanced Biomedical Sciences

Background & objective: Obesity, as a major health concern in developed and developing countries, has many outcomes for people, among which is infertility in women. Therefore, this study was conducted to evaluate the correlation between the Body Mass Index (BMI) and the hormonal parameters in patients with unexplained infertility and normal subjects.
Materials & Methods: This case-control study was conducted on 40 patients with unexplained infertility and 30 fertile women with inclusion criteria of Follicle-stimulating hormone (FSH)<10, BMI<30, Anti-Müllerian hormone (AMH)≥1, normal Antral follicle count (AFC), and under the age of 35 years, after obtaining the informed consents, in Valiasr Fertility Clinic of Imam khomeyni Hospital in 2013-2014. On the third day of menstruation, the hormonal profile (including LH, FSH, Thyroid stimulating hormone (TSH), Prolactin (PRL), and AMH was measured and then, 5 ml of blood was taken. In addition, the serum leptin was measured using the leptin ELISA kit, and the correlation between BMI and all the hormones was evaluated.
Results: In all samples, the mean age, hormonal profile, and BMI had no statistically significant difference in the two groups. A direct and significant correlation was observed between BMI and leptin (p=0.003), and also between FSH and BMI (p=0.012) in the fertile women group.
Conclusion: Given the presence of a correlation between leptin and BMI, and the effect of leptin on ovulation, it is recommended that the infertile women maintain the BMI in the normal range, exercise and put the physical activity in their daily life schedules.