:: Volume 6, Issue 2 (Summer 2016) ::
J Fasa Univ Med Sci 2016, 6(2): 194-201 Back to browse issues page
The Effect of 8 Weeks Endurance Training on Serum Levels of IL-10 and IL-8, and White Blood Cell Count in Women with Breast Cancer
Abdolreza Kazemi 1, Behjat Kalantari Khandani2, Afsoon Ashraf Ganjoei3
1- Department of Physical Education and Sport Sciences, School of Humanities, Vali-e-Asr University, Rafsanjan, Iran , rkazemi22@yahoo.com
2- Department of Oncology, Medical science university of Kerman, Kerman, Iran
3- Department of exercise physiology, faculty of Humanities, Islamic Azad University, Kerman, Iran
Abstract:   (5530 Views)

Background & Objective: The regular exercise training is known as a preventive and adjuvant therapy in inflammatory diseases such as cancer. The aim of this study was to determine the effect of the aerobic training on IL-10 and IL-8 levels and the count of white blood cells (WBC) in women with breast cancer.

Material & Methods: The statistical society of the present study included Kerman women with breast cancer. Forty patients with breast cancer were randomly divided into two groups: exercise (n = 20) and control (n = 20). The exercise group performed the endurance training for 8 weeks with the intensity between 40 to 55 percent of the target heart rate. Twenty four hours before the first session and 48 hours after the last session of the exercise protocol, blood samples were taken from both groups and then IL-10 and IL-8 levels in serum were measured by ELISA via a Boster kit.

Results: The results of the present study showed that 8 weeks of the endurance exercise training did not significantly increase the IL-10 (P=0.113) serum level, but increased the WBC count (p=0.019) and decreased the serum level of IL-8 (p=0.03) significantly.

Conclusion: According to the results of the present study, regular endurance training via decreasing the inflammatory factors can be considered as an effective factor along with other therapies in improving breast cancer.

Keywords: Endurance training, Breast cancer, IL-10, IL-8
Full-Text [PDF 929 kb]   (1529 Downloads)    
Type of Study: Research | Subject: Physiology
Received: 2015/12/3 | Accepted: 2016/02/10 | Published: 2016/09/10

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Volume 6, Issue 2 (Summer 2016) Back to browse issues page