%0 Journal Article %A Kohan, Leila %T Investigating the association of rs1862513 genetic variant in resistin gene with susceptibility to breast cancer %J Journal of Advanced Biomedical Sciences %V 7 %N 2 %U http://jabs.fums.ac.ir/article-1-1166-en.html %R %D 2017 %K Resistin, Breast cancer, Promoter, Genetic variant, %X Background & objective: Resistin is a unique hormone secreted from adipocytes. Recent data indicated that resistin levels have been associated with inflammatory markers; Due to the fact that chronic inflammation plays a role in breast cancer, it seems that resistin may present a molecular link between inflammation and breast carcinogenesis. The aim of this study was to investigate the association of rs1862513 promoter resistin gene variant with breast cancer risk. Material & Methods: For the purpose of this case-control study, 150 breast cancer and 150 healthy control blood samples were collected. After DNA extraction, genotype determination was performed by PCR-RFLP method. Statistical analysis was done using logistic regression model. Results: The case and control groups were in Hardy-Weinberg equilibrium. The subjects with GG genotype had increased risk of breast cancer compared to those with CC genotype (OR: 1.9, 95% CI: 1-3.7, P: 0.04). Also, the G allele indicated a positive association with breast cancer susceptibility (OR: 1.4, 95% CI: 1-1.98, P: 0.03). Conclusion: Results of this study showed possible association of resistin rs1862513 gene variant with breast cancer risk in Iranian women. %> http://jabs.fums.ac.ir/article-1-1166-en.pdf %P 217-222 %& 217 %! Resistin gene variant and breast cancer %9 Research %L A-10-1031-2 %+ 1- Department of biology, Arsanjan Branch, Islamic Azad University, Arsanjan, Iran 2- Young Researcher and Elite club, Arsanjan Branch, Islamic Azad University, Arsanjan, Iran %G eng %@ 2228-5105 %[ 2017