TY - JOUR T1 - The Roles of Long non-coding RNAs (lncRNA) in Prostate Cancer TT - نقش RNAهای غیر کد کننده طویل (LncRNA) در سرطان پروستات JF - JABS JO - JABS VL - 9 IS - 1 UR - http://jabs.fums.ac.ir/article-1-1805-en.html Y1 - 2019 SP - 1187 EP - 1199 KW - prostate cancer KW - long non-coding RNA KW - LncRNA N2 - Background & Objective: Prostate cancer is a compound condition in which gene expression has altered. Several surveys have revealed that genetic components have been involved in prostate cancer progression. Findings proposed that they can modify a noteworthy portion of disposing of elements, which is associated to the developing prostate cancer in protein coding sequences. The purpose of this research was to indicate that there are many long non-coding RNAs with over 200 nucleotides length found in the human genome, which showed a significant role in the pathogenesis of prostate cancer. Conclusion: The role of LncRNAs as tumor suppressors or oncogenes has been demonstrated in several types of cancers, including prostate cancer. Recent investigations have disclosed that LncRNAs transcripts play a pivotal role in the tumorigenesis. M3 ER -