@ARTICLE{Soltanihekmat, author = {javanmardi, kazem and soltanihekmat, ava and shekoohi, masoomeh and hasanein, parisa and bakhshi, mehdi and ghodsi, roghayeh and rezaeian, leila and Bordbar, Akhtar and }, title = {The Role of Parabrachial GABAA Receptors in Pain Modulation in Rats}, volume = {3}, number = {2}, abstract ={Background & Objective: The parabrachial nucleus is a critical link in the transmission of short latency nociceptive information to midbrain neurons. GABA(A) receptors have bidirectional roles in controlling nociception and are abundant in the parabrachial region . We examined the effects of bilateral intra parabrachial microinjection of different doses of the GABA(A) receptor agonist, muscimol, and the GABA(A) receptor antagonist, bicuculline, on pain modulation using a tail-flick test . Materials & Methods: Rats were anaesthetized with sodium pentobarbital (55 mg/kg) and then special cannulas were inserted stereotaxically into the parabrachial nucleus. After 1 week of recovery, the effects of microinjection of muscimol, (62.5, 125,250 ng/side) or bicuculline, (50,100,200 ng/side) into the parabrachial on tail flick latencies were assessed. Tail-flick latencies were measured for 60 minutes every 5 min after drug microinjection. Results: Microinjection of muscimol (62.5, 125 ng/side) and bicuculline (50,100,200 ng/side) into the parabrachial did not have any statistically significant effect on tail-flick latency. Administration of, muscimol, (250 ng/side) produced thermal hyperalgesia (P }, URL = {http://jabs.fums.ac.ir/article-1-282-en.html}, eprint = {http://jabs.fums.ac.ir/article-1-282-en.pdf}, journal = {Journal of Advanced Biomedical Sciences}, doi = {}, year = {2013} }