TY - JOUR T1 - Evaluation of Mexiletine Effect on Bispectral Index Changes and Hemodynamic Responses to Endotracheal Intubation and During General Anesthesia TT - ارزیابی اثر مگزیلتین بر تغییرات شاخص دو طیفی (Bispectral Index) و پاسخ‌های همودینامیک به دنبال لوله‌گذاری نای و حین بیهوشی عمومی JF - JABS JO - JABS VL - 4 IS - 2 UR - http://jabs.fums.ac.ir/article-1-176-en.html Y1 - 2014 SP - 243 EP - 250 KW - Mexiletine KW - Bispectral Index (BIS) KW - Hemodynamic Changes KW - Laryngoscopy and Tracheal Intubation N2 -   Background &Objective: Plaryngoscopy and tracheal intubation increase not only blood pressure and heart rate but also Bispectral Index (BIS) of the patients. In this study, hemodynamic and BIS changes were surveyed after tracheal intubation and during general anesthesia followed by mexiletine prescription . Materials & Methods: In this study, 50 patients aged between 20 and 60 who were candidates for orthopedic surgery of the upper limbs were surveyed. They were divided in two groups randomly. Two hours before induction of anesthesia,  case and control groups received mexiletine 200 mg as capsule and oral placebo, respectively. Systolic  and diastolic blood pressures ,heart rate, and BIS of both groups were compared before induction and intubation 1,3 and 10 minutes after intubation and immediately  , 15, 30, 45, and 60 minutes  after  surgical incision. Results: There was not any significant differences in systolic and diastolic pressures of the two groups.  The heart rate was lower in mexiletine group compared to control group, 30 minutes after surgical incision and immediately after extubation (P M3 ER -