RT - Journal Article T1 - Effects of 4 week endurance training on PGC-1α expression in adipose tissue, ANGPTL8 serum concentrations and beta cells function of STZ diabetic rats JF - JABS YR - 2018 JO - JABS VO - 8 IS - 4 UR - http://jabs.fums.ac.ir/article-1-1635-en.html SP - 1068 EP - 1078 K1 - Endurance Training K1 - Beta Cells proliferation K1 - PGC-1α K1 - ANGPTL8 AB - Background & Objective: Angiopoietin-like Proteins 8 (ANGPTL8) which secreted form adipose tissue due to downstream PGC-1α pathways, is the main factor for regeneration of beta cell. The aim of this study was to investigate the effect of 4 endurance training program on PGC-1α expression in adipose tissue, ANGPTL8 serum concentration and beta cell function (HOMA.B) in diabetic rats. Materials & methods: Male Wistar rats (N=24) divided in 3 groups include healthy control (HC), diabetic control (DC) and endurance training (ET). After induction of diabetes with STZ, training groups performed 4 weeks endurance training and real-time polymerase chain reaction (Real-Time PCR) method used for the relative expression of PGC-1α in visceral adipose tissue, the enzyme-linked immunosorbent assay (ELISA) method for measuring serum ANGPTL8 levels. Also beta cell number was counted with pancreases hematoxylin-eosin evaluation. Results analyzed with ANOVA. Results: The relative expression of mRNA PGC-1α was significantly increased in ET (P=0.001). Although ANGPTL8 levels increased in ET group, this change wasn’t significant (P=0.47). HOMA.B didn’t showed any significant change in ET (P=.0.08) but the number of beta cells in this group significantly increased (P=0.001). There was a positive correlation between relative mRNA PGC-1α and ANGPTL8 levels. Conclusion: Despite the positive and significant correlation between relative expression of mRNA PGC-1α and ANGPTL8, this increase wasn’t significant, but this could increases the number of beta cell in endurance training group. Further studies with differences training programs are recommended. LA eng UL http://jabs.fums.ac.ir/article-1-1635-en.html M3 ER -