AU - Bakhshi Ganje, Mohammad AU - Shekhha, Mohamad hassan AU - Farashahi, Ehsan AU - Mohammadzade, Morteza TI - Association of rs16953002 FTO Gene Polymorphism with Type 2 Diabetes and Obesity PT - JOURNAL ARTICLE TA - JABS JN - JABS VO - 6 VI - 1 IP - 1 4099 - http://jabs.fums.ac.ir/article-1-762-en.html 4100 - http://jabs.fums.ac.ir/article-1-762-en.pdf SO - JABS 1 ABĀ  - Background & Objective: Genome-wide association studies (GWAS) has identified that FTO gene polymorphisms was associated with the risk of type 2 diabetes and obesity. However, the findings in subsequent studies were inconsistent in various populations. This study aimed to investigate the association of FTO rs16953002 with type 2 diabetes and obesity in Yazd, Iran. Methods & Materials: Unrelated study subject controls (n=200) and type 2 diabetes cases (T2DM) (n=200), were randomly selected from Yazd, Iran. Genotyping was done by the polymerase chain reaction-restriction fragment length polymorphism method. Age and gender, smoking, weight and body mass index (BMI) were analyzed using the analysis of χ2 test. Results: The rs16953002 A/G polymorphism of the FTO gene showed significant association with T2DM and obesity. The AG, GG genotypes were significantly higher in T2DM and obese subjects compared to the group subjects. Conclusions: The result of the present study indicate that the genetic variant in FTO may contribute to T2DM and obesity risk in Yazd population. CP - IRAN IN - LG - eng PB - JABS PG - 27 PT - Research YR - 2016