Journal of Advanced Biomedical Sciences
مجله علوم زیست پزشکی پیشرفته
JABS
Medical Sciences
http://jabs.fums.ac.ir
1
admin
2228-5105
2783-1523
8
7
14
8888
13
en
jalali
1399
8
1
gregorian
2020
11
1
10
4
online
1
fulltext
fa
اثر نانوذرّات تیتانیوم دی اکساید بر توان باروری آزمایشگاهی در موش سفید کوچک آزمایشگاهی
Effect of Titanium Dioxide Nanoparticles on in Vitro Fertilizing Potential in Albino Mice
جنين شناسي
Embryology
پژوهشي
Research
<div style="text-align: justify;"><strong><em>Background & Objectives:</em></strong> Toxic free radicals produced by titanium dioxide nanoparticles have adverse effects on the reproductive system and can affect the semen quality and decrease fertility. The purpose of this study was to assess the effect of titanium dioxide on in vitro fertilizing potential in albino mice.<span dir="RTL"></span><br>
<strong><em>Materials & Methods:</em></strong> In this experimental study, 24 adult male mice were divided into 4 control and experimental groups. The experimental groups received titanium dioxide at 2.5, 5 and 10 mg/kg by gavage. After the end of the treatment period, animals were sacrificed by cervical dislocation and then sperm samples were collected from cauda epididymis to investigate in vitro fertilization. The level of <em>p</em><0.05 was considered significant.<br>
<strong><em>Results:</em></strong> In vitro fertilization results showed that titanium dioxide significantly reduced embryonic quality and stages of embryological development compared to the control animals. Also, the percentage of arrested embryos in the experimental groups was significantly enhanced versus the control (<em>p</em><0.05).<br>
<strong><em>Conclusion:</em></strong> The present results exhibited that oxidative stress produced by titanium dioxide causes sperm quality decline and decrease in vitro fertilizing potential in a dose-dependent manner.</div>
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Sperm, Titanium dioxide, Embryonic development, In Vitro Fertilization, Mouse
3035
3043
http://jabs.fums.ac.ir/browse.php?a_code=A-10-2520-4&slc_lang=fa&sid=1
Ramin
Jahangirfard
رامین
جهانگیرفرد
r.jahangirfard@urmia.ac.ir
5040067321
100319475328460024811
Yes
Department of Comparative Anatomy and Embryology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
گروه آناتومی و جنینشناسی مقایسه ای، دانشکده دامپزشکی، دانشگاه ارومیه، ارومیه، ایران