Journal of Advanced Biomedical Sciences
مجله علوم زیست پزشکی پیشرفته
JABS
Medical Sciences
http://jabs.fums.ac.ir
1
admin
2228-5105
2783-1523
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8888
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en
jalali
1400
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gregorian
2021
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online
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fulltext
en
Regular Exercise Training Enhances Spatial Memory and Regulates Glucocorticoid System in Experimental Autoimmune Encephalomyelitis
Regular Exercise Training Enhances Spatial Memory and Regulates Glucocorticoid System in Experimental Autoimmune Encephalomyelitis
اعصاب و روان
Neurology
پژوهشي
Research
<h3 style="text-align: justify;"><strong><em>Background & objective: </em></strong>Exercise has been shown to improve cognitive function in patients with multiple sclerosis (MS). Experimentally, glucocorticoids (GCs) treatment has been observed to improve cognitive deterioration in an autoimmune model for MS, experimental autoimmune encephalomyelitis (EAE). We aimed to determine the combined effect of exercise and 4 mg/kg of dexamethasone (Dex) for 4 weeks on spatial memory in EAE.<br>
<strong><em>Materials & Methods: </em></strong>Rats with EAE were subjected to the Morris water maze (MWM) for four days and a prop test for one day. The prop test was repeated on day 40 post-induction (dpi). Rats were randomly assigned to one of four groups (10 rats per group): control EAE without treatment; EAE + dexamethasone, (EAE + Dex); EAE + exercise (EAE + Ex); and EAE+Dex+Ex. Rats receiving dexamethasone were administered 4 mg/kg injections daily for two weeks after EAE induction. Exercise training was initiated on a motorized treadmill 2 weeks before EAE induction and continued until 14 dpi. On day 41, animals were dissected and CORT level was assessed by enzyme-linked immunosorbent assay corticosterone kit.<br>
<strong><em>Results:</em></strong> One-way analysis of variance (ANOVA) with repeated measures followed by a protected LSD post hoc test indicated that, EAE+Ex group increased body weight (P < 0.001) and it displayed a significantly lower CORT concentration (P <0.001) with delayed clinical score until day 13 dpi. Further EAE+Ex improved memory by time spent (p > 0.001) and swimming speed (p>0.002).<br>
<strong><em>Conclusion</em></strong>: The protocol selected in this study was an effective treatment for the EAE model to improve spatial memory and regulate corticosterone concentrations.</h3>
Regular Exercise, Experimental Autoimmune Encephalomyelitis, Dexamethasone, Memory, Corticosterone
4067
4076
http://jabs.fums.ac.ir/browse.php?a_code=A-10-2881-1&slc_lang=en&sid=1
Muthanna
Hafedh
مثنی
حافظ
a.parnow@razi.ac.ir
100319475328460026447
100319475328460026447
No
Department of Exercise Physiology, Faculty of Sports Sciences, Razi University, Kermanshah, Iran
گروه فیزیولوژی ورزشی، دانشکده علوم ورزشی، دانشگاه رازی، کرمانشاه، ایران
Abdolhossein
Parnow
عبدالحسین
پرنو
parnowabdolhossein@gmail.com
100319475328460026448
100319475328460026448
Yes
Medical Biology Research Center, Department of Anatomical Sciences, Kermanshah University of Medical Sciences, Kermanshah, Iran
مرکز تحقیقات زیست پزشکی، گروه علوم تشریح، دانشگاه علوم پزشکی کرمانشاه، کرمانشاه، ایران
Cyrus
Jalili
سیروس
جلیلی
100319475328460026449
100319475328460026449
No
Medical Biology Research Center, Department of Anatomical Sciences, Kermanshah University of Medical Sciences, Kermanshah, Iran
مرکز تحقیقات زیست پزشکی، گروه علوم تشریح، دانشگاه علوم پزشکی کرمانشاه، کرمانشاه، ایران
Drapan
Patel
دراپن
پتل
patelD7@uthscsa.edu
100319475328460026450
100319475328460026450
No
Faculty of Nursing, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
دانشکده پرستاری، مرکز علوم بهداشتی دانشگاه تگزاس در سن آنتونیو، سن آنتونیو، تگزاس، ایالات متحده آمریکا
Ikuo
Tsunoda
آیکو
سانودا
100319475328460026451
100319475328460026451
No
Department of Microbiology, Faculty of Medicine, Kindai University, Osaka, Japan