Journal of Advanced Biomedical Sciences
مجله علوم زیست پزشکی پیشرفته
JABS
Medical Sciences
http://jabs.fums.ac.ir
1
admin
2228-5105
2783-1523
8
7
14
8888
13
en
jalali
1401
8
1
gregorian
2022
11
1
12
4
online
1
fulltext
en
The Effects of COVID-19/ACE2 on Pregnancy Events and Outcomes: A Systematic Review
فيزيولوژي
Physiology
مروری
Review
<div style="text-align: justify;"><span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,sans-serif"><b><i><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Background & Objectives:</span></span></i></b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""> Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) was confirmed as the cause of Coronavirus disease 2019 (COVID-19). The disease presents with a wide range of clinical signs and symptoms involving vital organs such as the lungs, heart, gastrointestinal tract, liver, central nervous system, blood, and kidneys. It also potentially affects other organs, including the placenta.The present systematic review aimed to evaluate effects of SARS-CoV-2 on pregnant women, fetuses, and infants born to infected mothers.</span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,sans-serif"><b><i><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Material & Methods:</span></span></i></b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""> <span style="color:black">The search fields used in this study were </span>angiotensin-converting enzyme receptor (ACE2), <span style="color:black">fetus, pregnancy, and SARS-CoV-2. </span>We reviewed articles published in 2020 and 2022. </span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">The inclusion criteria were articles on receptor expression, virus entry into the host cell, studies on the characteristics and outcomes of pregnant or recently pregnant women with SARS-CoV-2 infection who were approved and characteristics and outcomes of infants whose mothers were infected with SARS-CoV-2.</span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,sans-serif"><b><i><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Results:</span></span></i></b><b> </b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">The virus uses the ACE2 to enter the cell. The coronavirus can be expected to affect any cell or organ that expresses ACE2. Female reproductive system is one of the systems that express ACE2. The destructive effects of COVID-19 on maternal and fetal health are strongly influenced by the spatial-temporal distribution of ACE2. </span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span style="font-family:Calibri,sans-serif"><b><i><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Conclusion:</span></span></i></b><b> </b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">The harmful role of COVID-19 in pregnancy is highly controversial, although maternal COVID-19 infection contributes to adverse consequences of pregnancy. There is a limited amount of information on the efficacy of COVID-19 on pregnants and their fetuses. </span></span></span></span></span></div>
COVID-19, Pregnant women, Fetus, ACE-2, SARS-CoV-2, Neonate
346
354
http://jabs.fums.ac.ir/browse.php?a_code=A-10-2445-2&slc_lang=en&sid=1
Azizeh
Sadeghzadeh
عزیزه
صادق زاده
100319475328460026837
100319475328460026837
No
Department of Biology, Faculty of Science, University of Mohaghegh Ardabili, Ardabil, Iran
گروه زیست شناسی، دانشکده علوم، دانشگاه محقق اردبیلی، اردبیل، ایران
Firouzeh
Sadeghzadeh
فیروزه
صادق زاده
Firouzeh.sadeghzadeh@gmail.com
100319475328460026838
100319475328460026838
No
Department of Biology, Faculty of Science, Arak University, Arak, Iran
گروه زیست شناسی، دانشکده علوم، دانشگاه اراک، اراک، ایران
Fariba
Mahmoudi
فریبا
محمودی
f.mahmoudi@uma.ac.ir
100319475328460026839
100319475328460026839
Yes
Department of Biology, Faculty of Science, University of Mohaghegh Ardabili, Ardabil, Iran
گروه زیست شناسی، دانشکده علوم، دانشگاه محقق اردبیلی، اردبیل، ایران