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Fasa University of Medical Sciences
Journal of Advanced Biomedical Sciences
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158
article
Treating a Patient with Bone Marrow Edema Syndrome with Iloprost
mojtaba piri
mpiri1368@gmail.com
1
mohammadsaleh sadeghi
salehsadeghi87@gmail.com
2
Student Research Committee, Kerman University of Medical Scinences, Kerman, Iran.
Student Research Committee, Qom University of Medical Sciences, Qom, Iran.
Bone Marrow
Edema Syndrome (BMES) is an uncommon, self-limited and with unknown etiology
characterized by severe pain with no history of trauma. Due to low prevalence
of BMES and its non-specific signs, correct diagnosis is often delayed
intensifying bone pain and impairing patients’ function and quality of life. In
this study we treated a patient with bone marrow edema syndrome in right ankle
with Iloprost successfully that suffered pain in this region almost 4 months
and NSAID, physiotherapy and steroid treatments was not benefited.
http://jabs.fums.ac.ir/article-1-754-en.pdf
Iloprost
Bone marrow edema syndrome
Physiotherapy
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Fasa University of Medical Sciences
Journal of Advanced Biomedical Sciences
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167
article
Surveying Global and Iranian Food Consumption Patterns: A Review of the Literature
fatemeh abdi
abdi@sbmu.ac.ir
1
zahra atarodi
abdi@sbmu.ac.ir
2
parvin mirmiran
fatemeh.abdi87@yahoo.com
3
taraneh esteki
fatemeh.abdi87@yahoo.com
4
Students Research Committee, Nursing and Midwifery Faculty, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Nursing and Midwifery Faculty, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Clinical Nutrition and Diet Therapy, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Basic Sciences, Nursing and Midwifery Faculty, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Identifying global
and regional food consumption patterns, which vary in different countries,
races, social classes, and cultures will be beneficial in training individuals,
promoting food literacy, and nutrition policy making. In order to compare
Iranian and global food consumption patterns, a number of relevant key terms
were selected and the existing quality literature databases (both in English and
in Persian) were queried for manuscripts related to the subject. The articles
were published until the current time (2014). Manual searches were also
performed on regional and national projects in Iran. Finally, out of 65 studies
on various food patterns, 39 were recruited. Our findings indicated that per
capita calorie consumption in Iran is higher than the recommended daily values.
In fact, per capita intakes of bread and rice, oil, and sugar were respectively
5%, 20%, and 38% higher than the rates in the standard food basket. In
addition, consumption of milk and dairy products, eggs, and fruits and
vegetables was 25%, 20%, and 25% lower than the recommended values,
respectively. Changes in global food consumption patterns suggested a nutrition
transition leading to serious undesirable effects on people’s health.
Therefore, nutrition policy making and planning is needed to focus on
controlling the nutrition transition while bearing sociocultural aspects of
food consumption in mind.
http://jabs.fums.ac.ir/article-1-677-en.pdf
Food consumption pattern
Food basket
Iran
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Fasa University of Medical Sciences
Journal of Advanced Biomedical Sciences
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184
article
The Effect of Prangos Ferulacea L on the Haematologic Indices of Diabetic Rats
Saeedeh Hojabrian
saiedeh_hojhabrian@yahoo.com
1
padideh Ebadi
padideh_ebadi@yahoo.com
2
Mokhtar Mokhtari
mokhtar_mokhtary@yahoo.com
3
Department of Biology, Faculty of Basic Sciences, Kazerun Branch, Islamic Azad University, Kazerun, Iran.
Department of Biochemistry, Faculty of Medicine, Kazerun Branch, Islamic Azad University, Kazerun, Iran.
Department of Biology, Faculty of Basic Sciences, Kazerun Branch, Islamic Azad University, Kazerun, Iran.
Background & Objective: Diabetes mellitus is a heterogenic metabolic disease in which hyperglycemia leads to glycosylation of RBC membrane and damage of bone marrow stem cells. Because of high flavonoid content of Prangos Ferulacea lindl, the effects of its aqueous- alcoholic extracts on hematologic incidences of diabetic male rats have been studied.
Materials & Methods: In this study, 60 adult male rats of Wistar race, (body weight 200±20 g) were divided randomly into 6 groups of 10 members. The control group did not receive any medication or herbal extract, while the blank group received the solvent alone. Test group 1 was administered by 300 mg/kg.bw prangos Ferulacea extract as gavages. Test group 2 received only 60 mg/kg. bw intraperitoneal strptozotocin. Test group 3 and 4 were administered by 300 mg/kg.bw and 600 mg/kg.bw Prangos Ferulacea extract, respectively. After 28 days of administration, the serum of all groups were collected and the hematologic parameters were assessed. The data were statistically analyzed by ANOVA test. In all tests, we normally worked with significance value of 0.05.
Result: According to the statistical results, Test group 2 showed a significant decrease in RBC, HCT, Hb, and MCH in comparison with control group, while test groups 3 and 4 showed an enhancement in RBC, HCT, Hb, and MCV parameters comparing the test group 2.
Conclusion: It is concluded that aqueous-alcoholic extract prangos ferulacea L. can improve some hematologic incidences including red blood cells, hemoglobin, and hematocrit.
http://jabs.fums.ac.ir/article-1-617-en.pdf
Prangos Ferulacea Lindle
Diabetes mellitus
Hematologic Parameters
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Fasa University of Medical Sciences
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195
article
The Effect of Vitrification on Follicular Morphology of Ovarian Rat
Foroozan Esmaeilzadeh
rahsepar88@yahoo.com
1
Laleh Hamedi
sctrc@sums.ac.ir
2
Davood Mehrabani
mehrabad@sums.ac.ir
3
Aalamtaj Bidshahri
A_sh125@yahoo.com
4
Nader Tanideh
tanidehn@gmail.com
5
Department of Chemistry, Islamic Azad University, Marvdasht Branch, Marvdasht, Iran
Department of Biology, Islamic Azad University, Jahrom Branch, Jahrom, Iran
Department of Biology, Islamic Azad University, Jahrom Branch
Department of Biology, Islamic Azad University, Jahrom Branch, Jahrom, Iran
Department of Chemistry, Islamic Azad University, Marvdasht Branch
Background & Objective: Some efforts have been made for keeping cryopreservation of gametes and embryos safe, including new vitrification methods of the ovary. This study evaluates the effect of ethylene glycole vitrification on follicular morphology of ovarian rat.
Materials & Methods: Eighty ovaries belonging to 40 rats are divided into 2 groups. Twenty five ovaries are control group, 25 the vitrification, and30 toxicologic effects. For freezing, equilibrium solution, ethylene glycole and methyl sulfoxide are used. For defreezeing, different concentrations of saccharose and for morphological evaluation, H&E staining are undertaken. The number of healthy and atretic follicles are determined after 24 hours, 1 week and one month after vitrification.
Results: No morphological changes are observed in all follicular cells. The percent of primordial, primary, secondary, anthral and developed follicles in the vitrification group are 34.5%, 17.7%, 17.4%, 15.2% and 50.3%. In vitrification and toxicological groups, the percent of both normal and atretic follicles is 47.5% and 11.9%. These figures for the control group were 59.7% and 16.9%. In vitrification method, 91% of oocytes are viable, 81% have mitosis, and 50% enters blastocyst stage.
Conclusion: Because in vitrification of ovary in comparison with the follicles, many types of follicles in different cycles can be recovered with no morphological and structural changes, vitrification of ovary can be a safe method for cryopreservation of the oocytes
http://jabs.fums.ac.ir/article-1-608-en.pdf
Vitrification
Follicle
Oocyte
Ovary
Morphology
Rat
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Fasa University of Medical Sciences
Journal of Advanced Biomedical Sciences
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201
article
Assessment of HCV Infection in Suspected Orphans Newborns by Real-Time PCR and HCV-Core Ag-Elisa
Marzieh Jamalidoust
1
Mandana Namayandeh
2
Maryam Zare
3
Mazyar Ziyaeyan
ziyaeyanm@sums.ac.ir
4
Department of Medical Virology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Prof. Alborzi Clinical Microbiology Research Center, Nemazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
Prof. Alborzi Clinical Microbiology Research Center, Nemazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
Prof. Alborzi Clinical Microbiology Research Center, Nemazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
Background & Objective: HCV infection may be transmitted from an infected mother to her fetus in a low percentage however, it is the most important route of infancy HCV infection. The chance of HCV transmission in HIV/HCV co-infected mothers is higher than that in HCV mono-infected ones. The aim of this study is to assess HCV infection status in orphan newborns in Shiraz, Iran by quantitative PCR assay and HCV core-Ag Elisa.
Materials & Methods: Twenty nine HCV suspected infants, 2-7 months old, were evaluated for HCV and HIV antibodies, HCV core antigen and quantitative genome viral load.
Results: Although HCV-Ab was detected in all the studied infants, HCV-RNA was not detected in plasma or Peripheral Blood Mono-Nuclear Cells (PBMCs). HIV 1, 2 Abs were not detected in none of them, either.
Conclusion: A few studies have been conducted on the HCV transmission from infected mothers to their infants. According to the present results, assessment of HCV viral load and HCV core-Ag can serve as reliable tests for the prediction or exclusion of HCV infection from mothers to infants.
http://jabs.fums.ac.ir/article-1-560-en.pdf
HCV infection
Orphan newborn
Quantitative PCR
HCV-core Ag
per
Fasa University of Medical Sciences
Journal of Advanced Biomedical Sciences
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2015-08
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202
209
article
The Relationship Between Duration of Breastfeeding and Maternal Factors
Farhad Jafari
jafarifarhaddr@yahoo.com
1
Houriyeh Farahrooz
2
Zeinab Abyar
3
Behzad Tadayyon
4
Fateme Azami
5
Department of social medicine, school of medicine, shahed university, Tehran, Iran.
School of medicine, shahed university, Tehran, Iran.
School of medicine, shahed university, Tehran, Iran.
School of medicine, shahed university, Tehran, Iran.
Department of Science in Medicinal Plants, Ministry of Agriculture, Tehran, Iran.
Background & Objective: Breast milk is the best food for infants and provides all nutritional needs for child health.
Some studies have been done on the factors affecting breastfeeding, and partly, the role of factors such as maternal diseases and wrong recommendations are known.
Materials & Methods: This is a cross sectional study with descriptive and analytical aspects. The sample includes 355 people from Tehran. Data were collected through questionnaires and were analyzed with SPSS software and statistical test. Significant level was considered at the 0.05.
Results: The average of age, weight, and height of the subjects were 42.09 years, 67.2 kg and 160.3 cm respectively. The mean body mass index (BMI) was 26.15. More than half of mothers (59.5%) were overweight or obese. In addition, 55.5% had higher education. 45.4% of mothers had 2 children. The average age at first birth, and last was, 24.22 and 30.86 years, respectively. 58.7% of mothers were taking Oral Contraceptives Pills (OCPs). 11.9% of mothers had never breastfed their children. The average duration of breast-feeding was 11.75 months. This study suggests that there is no statistically significant relationship between the duration of breast feeding and age, height, educational level, place of work, taking OCP, exercise and emotional status of the mother (P>0.05). However, it is associated with gaining weight and increase of BMI and age at first birth and increases with them.
Conclusion: Mothers breastfed their children about a year and duration of breastfeeding were associated with body mass index and age at first birth.
http://jabs.fums.ac.ir/article-1-386-en.pdf
breastfeeding
BMI
maternal factors
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Fasa University of Medical Sciences
Journal of Advanced Biomedical Sciences
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218
article
Ergonomic Evaluation of the Risk of Suffering from Musculoskeletal Disorders in Nurses with Quick Exposure Check (QEC) and the Effect of 8-week selected Corrective Exercises and Ergonomic Occupational Intervention on their Exposure Rate
Raziye Karimian
karimianrazieh@yahoo.com
1
Nader Rahnama
2
zeinab karimimoghaddam
3
Maryam Karimian
4
Azam Janbozorgi
5
Faculty of Physical Education & Sports Sciences, University of Isfahan, Isfahan, Iran.
Faculty of Physical Education & Sports Sciences, University of Isfahan, Isfahan, Iran.
University of Fasa, Fasa, Iran
University of Fasa, Fasa, Iran
Faculty of Physical Education & Sports Sciences, University of Birjannd, Birjand, Iran.
Background & Objective: In order to reduce work-related musculoskeletal disorders in ergonomic approach, all effective factors in occurrence of disorders, should be evaluated. This approach can provide an optimal solution for the omission or reduction of work-related musculoskeletal disorders. The aim of the present study is ergonomic evaluation of nurses’ risk of suffering from musculoskeletal disorders with Quick Exposure Check(QEC) and the effect of 8-week selected corrective exercises and ergonomic occupational interventions on their exposure rate.
Materials & Methods: Therefore, Nordic questionnaire and Quick Exposure Check of the factor risk were applied for 6 tasks of nurses.
Results: 85.7% of nurses reported occupation as the major factor for musculoskeletal disorders and 89% of nurses’ tasks studied were in high or very high risk. There was a significant difference in care techniques used by nurses (P<0.05). Moving up patients (87.7%) had the highest risk and giving drugs (66.2%), determining the vein (65.1%), dressing a wound, participation in visiting patients (59.9%), and reporting (51.1%) were in the following risk orders. After 8 week corrective exercises and ergonomic interventions there was a significant reduction in the risk rate of suffering from musculoskeletal disorders in 6 tasks by nurses (P<0.05 ).
Conclusions: The results show that high risk level was a sign for susceptible conditions and workplaces in the hospital and corrective technique of moving up patients and improved conditions for moving up patients, improved other care techniques and selected corrective exercises reduced the risk level.
http://jabs.fums.ac.ir/article-1-916-en.pdf
Musculoskeletal Disorder
Occupational Ergonomic
QEC
Corrective Exercises
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Fasa University of Medical Sciences
Journal of Advanced Biomedical Sciences
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228
article
The effects of Intracerebellumal Injection of Estrogen on Anxiety-like Behavior and Parameters of Antioxidant System following Ethidium Bromide Injection in rat
faranak nejati
1
shiva khezri
skhezri72@gmail.com
2
homeira hatami
3
ali reza ali hemmati
4
Department of Biology, Facultyof Science, Urmia University, Urmia, Iran.
Department of Biology, Facultyof Science, Urmia University, Urmia, Iran.
Department of Animal Biology, Faculty of Natural Science, University of Tabriz, Tabriz, Iran
Department of Anatomy and Histology, Faculty of Medicine, Tabriz University of Medical Science, Tabriz, Iran.
Background & Objectives: Demyelination by Ethidium bromide is one of the ways that is usually used for preparing experimental models of MS. Treatment with estrogen protects oligodendrocyts from cell poisoning and stops lipidic peroxidation. The aim of this study is the evaluation of the effects of estrogen on anxiety like behavior and stress oxidative parameters after inducing demyelination by ethidium bromide to the cortex of cerebellum in rats.
Materials & Methods: Induction of demyelination was carried out in cerebellum cortex by direct injection of Ethidium Bromide (EB) (0.01%). One week after injection of EB, animals were treated with two doses of estrogen (2µg/μl and 4µg/μl) for 3 days. After the treatment stage, characteristics of anxiety were assessed by using Elevated plus Maze moreover , the parameters of stress oxidative were evaluated. One-way Analysis of Variance (ANOVA) was performed.
Results: The results of this study showed that Open Arm Entry percentage and open arm time (anxiety index) in rats with estrogen treatment was significant relative to Ethidium Bromide group (p<0.01) in addition , activity value of glutathione peroxidase and catalase showed significant increase compared to Ethidium Bromide group.
Conclusion: Microinjection of estrogen can decrease anxiety as well as oxidative stress.
http://jabs.fums.ac.ir/article-1-684-en.pdf
Ethidium Bromide
Estrogen
Anxiety
Cerebellum
Oxidative stress
Rat
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Journal of Advanced Biomedical Sciences
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236
article
Effect of Intravenous Analgesia Pump on Neonates and the Complaints and Complications of Mothers after Cesarean Section
Majid Ahmadi
majid.ahmadi@muk.ac.ir
1
Negin Rezavand
nRezavand@kums.ac.ir
2
Ali Reza Ghorbani
araaaara1111@yahoo.com
3
Amir Rezaei
amirrezaei0098@gmail.com
4
Department of Anatomy, Kurdistan University of Medical Science, Sanandaj, Iran.
Department of Obstrics & Gynecology, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Department of Anesthesia, Sadjad Hospital, Kermanshah, Iran
Department of Anesthesia, Kermanshah University of Medical Sciences, Kermanshah, Iran
Background & Objective: In this study the effects of this method on neonatal and the complaints and complications of mothers after Cesarean section by using pharmaceutical composition with opioids in intravenous analgesia pump are examined.
Materials & Methods: This study is an unidirectional clinical trial with a purposive sampling method on100 patients undergoing elective cesarean section in 2014 were admitted to the Sadjad hospital in Kermanshah. The patients were divided into two groups of 50 people, namely, pain control by using intravenous injection pump (intervention group) and pain control by using non-steroidal anti-inflammatory drugs (control group). Data collection tools, including check list of demographic, maternal and neonatal reflexes of discharge and a week after Cesarean. T-student test was used to compare quantitative variables and ratio test was used to compare qualitative variables. P values less than 0.05 were considered significant.
Results: Test results showed statistically significant differences in maternal complications between the intervention and control group at discharge (p<0/001). However, no significant difference in overall complications for the mothers between the intervention and control group during the first week after cesarean were showed. Also, in the case of neonatal reflexes no significant differences between the two groups were observed.
Conclusion: By adding pharmaceutical compounds to the intravenous pumps, it is possible to provide further use of this method of analgesia in women who have undergone Cesarean.
http://jabs.fums.ac.ir/article-1-704-en.pdf
Intravenous analgesia pump
Cesarean Section
Controlled clinical trial.
per
Fasa University of Medical Sciences
Journal of Advanced Biomedical Sciences
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2783-1523
2015-08
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237
247
article
Evaluation of Knowledge Regarding to Oral Manifestation of AIDS among General Dentists in Kermanshah, 2014
neda Omidpanah
n.omidpanah@yahoo.com
1
najmeh salehifar
najmehsalehi@ymail.com
2
Faculty of Dentistry, University of Medical Sciences, Kermanshah, Iran.
Faculty of Dentistry, University of Medical Sciences, Kermanshah, Iran.
Background & Objective: Oral lesions are the primary manifestations of HIV infections. The aim of this study is to evaluate the knowledge towards oral manifestations of AIDS among general dentists.
Materials & Methods: This cross-sectional study has been conducted by a self-administrated questionnaire on general dentists in Kermanshah city, 2014. The questionnaire contained demographic information and the part assessing knowledge. The correct answers in percent was considered as the knowledge level, that was classified by poor, intermediate, good, and excellent levels. The questionnaire reliability was confirmed by Cronbach alpha=0.79. Data were analyzed by SPSS 17 by using ANOVA, tukey and t-test (P< 0.05).
Results: A total of 120 general dentists including 76 males (63.3%) and 44 females (36.7%) with mean age of 36.4±9.3 years completed the questionnaires. Of the dentists, 1.7% presented excellent, 23.3% good, 48.3% intermediate, and 26.7% poor level regarding to total knowledge about AIDS/HIV. With respect to AIDS-related oral lesions, only 7.5% had excellent and 9.2% displayed good knowledge. Among dentists, intermediate and poor levels were observed in 35% and 48.3%, respectively. The dentists’ knowledge of AIDS-related oral manifestations revealed no significant relationship to age, gender, work experience, or attendance in educational workshops (P>0.05).
Conclusion: The dentists’ knowledge about oral lesions of AIDS was not in an acceptable level, suggesting improvement of their awareness about AIDS/HIV and its oral lesions.
http://jabs.fums.ac.ir/article-1-779-en.pdf
AIDS
Oral Lesions
Knowledge
General Dentists
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Fasa University of Medical Sciences
Journal of Advanced Biomedical Sciences
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256
article
Frequency of Side Effects of Methadone Maintenance Therapy in Patients Referred to Fasa Doctor Shariati Hospital
mohammad saied gholami
m_s_gholami@yahoo.com
1
reza alipoor
alipoor91.fums@yahoo.com
2
tayebeh zareie
zare.elaheh@yahoo.com
3
fatemeh rezaieyan
reza_alipoor16@yahoo.com
4
arvin hedayati
dr.arvinhedayati@gmail.com
5
Student Research Committee, Fasa University of Medical Sciences, Fasa, Iran.
Student Research Committee, Fasa University of Medical Sciences, Fasa, Iran.
Student Research Committee, Fasa University of Medical Sciences, Fasa, Iran.
Student Research Committee, Fasa University of Medical Sciences, Fasa, Iran.
Department of Psychiatry, Fasa University of Medical Sciences, Fasa, Iran
Background & Objective: Drug abuse causes severe gastrointestinal, neurological problems and dependency. For maintenance therapy of opiate addiction, long-acting opioids like methadone are used. Since incorrect use of methadone, leads to serious complications, this study aimed to evaluate the prevalence of methadone.
Materials & Methods: This cross-sectional study was done with a sample size of 151 patients in addiction treatment centers Fasa Shariati Hospital, during 6 months. After reviewing the cases of patients who were taking methadone for addiction and completed their demographic information, check list of questions about the different effects of methadone was completed for each patient. The data was statistically analyzed by Mann-Whitney test.
Results: The average age of participants in the scheme was 31/71. The results showed that the most common side effects of methadone, is gastrointestinal complications (77/5 percent). In addition, between the effects and duration of methadone there is a significant relationship. However, other effects were not associated with duration of use.
Conclusion: According to the results, the need for continuous follow-up of patients undergoing methadone treatment for drug complications and such findings can even be transferred to the relevant authorities, in order to add assessment side effects of treatment is necessary in the case of defined. The patients’ need to medication may cause endurance of bothersome symptoms. While it can affect their quality of life.
http://jabs.fums.ac.ir/article-1-705-en.pdf
Maintenance treatment
Methadone Maintenance Therapy
Addiction
Symptoms
Fasa
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Fasa University of Medical Sciences
Journal of Advanced Biomedical Sciences
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2015-08
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257
268
article
The Effects of Soy Milk on Histomorphometric Changes of Olfactory Bulb in Neonatal Ovariectomized RatsSprague- Dawley strain
Mohammad Ebrahim Astaneh
meastaneh@yahoo.com
1
Mina Tadjalli
2
Mahnaz Taherianfard
3
Department of Anatomy,Department of Basic Sciences, Faculty of Medicine, FasaUniversityof Medical Sciences,Fasa, Iran.
Department ofHistology,Department of Basic Sciences, Faculty of Veterinary Medicine, Shiraz University, Shiraz, Iran.
Department of Physiology, Department of Basic Sciences, Faculty of Veterinary Medicine, Shiraz University, Shiraz, Iran.
Background & Objective: Soy milk contains isoflavones that comprises the phytoestrogens families. They have structural similarities with mammalian estrogen. This study was done to investigate the effects of soy milk on histomorphometric changes of olfactory bulb in neonatal ovariectomized rats.
Materials & Methods: Thirty female rats Sprague- Dawley strain (one-day old) were kept in a standard laboratory condition. Afterwards, they were randomly divided into six groups with 5rats (a control, a sham and four experimental groups). The ovaries of one-week old experimental groups were removed by surgery. In experimental groups of 2,3and 4, the rats received soy milk twice a day from the 14th day to the end of 2 month 0.75, 1.5 and 3 ml/kg respectively by gavage. At the end of two month and after anesthesia and blood sampling to measure estrogen hormone, the olfactory bulb of all rats to investigate the thickness of layers and the number of cells in different layers of olfactory bulb histomorphometric was divided. Finally the results were analyzed through One-way variance and Tukey Test considering p<0.05.
Results: According to this study, the following results were obtained. Low estrogen level due to ovariectomized infant rats has reduced the thickness of external granular layer. Mitral cell layer and internal plexiform layer as well as cell number in most layers of the olfactory bulb through feeding high level of soy milk to ovariectomized infants leading to high serum concentrations of 17-β estradiol that subsequently increased thickness and cell numbers of olfactory bulb.
Conclusions: The soy milk can be used as a source of synthetic hormone replacement.
http://jabs.fums.ac.ir/article-1-558-en.pdf
Soy milk
Olfactory bulb
Ovariectized Rat
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Fasa University of Medical Sciences
Journal of Advanced Biomedical Sciences
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2015-08
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269
277
article
Studying the Frequency of Favorable Allele of rs12979860 Polymorphism of IL-28B in Healthy and HCV Infected Iranian Individuals
Abdolvahab Alborzi
alborziiraj2004@yahoo.com
1
Tayebeh Hashempour
tmhashempour@yahoo.com
2
Mahboobe Mirhoseini
3
nasim Adim
4
Javad Moayedi
javad.moayedi88@gmail.com
5
Zahra Musavi
zahra.mousavei@gmail.com
6
Shahin Merat
shahin.merat@gmail.com
7
Gholam Reza Pouladfar
pooladfar@sums.ac.ir
8
Mehrdad Hallaji
Mehrdad.md69@gmail.com
9
Farzaneh Ghassabi
farzanegh92@gmail.com
10
Arghavan Haj-Sheykholeslami
arghavan_sheykh@yahoo.com
11
Professor Alborzi Clinical Microbiology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
Professor Alborzi Clinical Microbiology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
Biology Department, Payame Noor University, Iran.
Biology Department, Payame Noor University, Iran.
Professor Alborzi Clinical Microbiology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
Professor Alborzi Clinical Microbiology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Professor Alborzi Clinical Microbiology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
Professor Alborzi Clinical Microbiology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
Professor Alborzi Clinical Microbiology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Background & Objective: Hepatitis C Virus (HCV) is one of the important risk factors for liver cirrhosis and hepatocellular carcinoma. Some of the host genetic factors such as interleukin 28B (IL-28B) may influence the response to the antiviral therapy. IL28B is a member of the interferon (IFN) family which causes an antiviral response. Previous studies indicated that rs12979860 polymorphisms of the IL-28B gene can influence persistent antiviral response. Therefore, in this study, the frequency of genotypes of rs12979860 polymorphisms in two groups of healthy and HCV infected Iranian individuals were evaluated.
Materials & Methods: In this cross sectional study, PCR-RFLP method was used to evaluate the frequency of genotypes of rs12979860 polymorphisms in 105 healthy individuals and 105 chronic HCV infected patients.
Results: The frequency of rs12979860 genotypes in healthy individuals was CC: 50.5%, CT: 45.7%, and TT: 3.8%. In HCV infected patients it was CC: 22.9%, CT: 63.8%, and TT: 13.3%. The frequency of rs12979860 genotypes had significant difference between two groups however it is not associated with sex.
Conclusion: A significant difference was observed between healthy individuals and HCV infected patients in the frequency of rs12979860 genotypes. The favorable CC genotypes and unfavorable TT genotypes was more detected in healthy individuals and HCV infected patients, respectively.
http://jabs.fums.ac.ir/article-1-641-en.pdf
Hepatitis C Virus
Interlukin-28
PCR-RFLP
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Fasa University of Medical Sciences
Journal of Advanced Biomedical Sciences
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2015-08
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287
article
The Effect of Moderate Intensity Running Exercise on Femoral Bone Microarchitectures in Ovariectomized Sprague-Dawley Rats
Sarah Hojjati
Sarah_hojjati@yahoo.com
1
Farzad Nazem
Sarah_hojjati@yahoo.com
2
Farhad Daryanoosh
daryanooshf@yahoo.com
3
Salman Vojdani
salman6365@yahoo.com
4
Department of Sport Physiology, Faculty of Physical Education and Sport Sciences, Bu-Ali Sina University, Hamedan, Iran.
Department of Sport Physiology, Faculty of Physical Education and Sport Sciences, Bu-Ali Sina University, Hamedan, Iran.
Department of Sport Physiology, Faculty of Education and Psychology, Shiraz University, Shiraz, Iran.
Department of Anesthesiology and Intensive care, Fasa University of Medical Sciences, Fasa, Iran.
Background & Objective: One of the most serious health problems is osteoporosis and it is mandatory to find preventive methods to confront this difficulty. Non-pharmacological methods are in priority due to less side effects. This study investigated the effect of treadmill running exercise on bone microarchitectures in female osteoporotic rats induced by ovariectomy.
Materials & Methods: 30 rats were randomly divided into three groups of control, experimental one, and experimental two. Control and Experimental one (Ovariectomized) groups were kept in control conditions. The Experimental group two was subjected to 10 weeks treadmill running exercise from the 12th- post operative week. The animals were weighted in all the stages of the protocol. Finally, all rats were sacrificed and their femoral bones were removed for bone strength and bone microarchitectures analysis by using One-Way ANOVA test. The Repeated Measure was used to analyze the weight changes during the study.
Results: The results showed that despite the same initial weight among groups (P=0.31), weight increased significantly in 12th and 22th postoperative weeks (P<0.001). Ovariectomy induced a significant decrease in Trabecular Thickness (TT) and Cortical Thickness (CT) (P<0.001). It also induced a weakened femoral bone strength (P=0.003). The levels of TT, CT, and bone strength increased in experimental group two compared to experimental group one and Trabecular Separation (TS) decreased, either (P<0.001).
Conclusion: The results indicated that a moderate intensity treadmill running exercise has a protective effect on osteoporotic bones.
http://jabs.fums.ac.ir/article-1-766-en.pdf
Osteoporosis
Weight-Bearing Exercise
Ovariectomy
Bone Loss
Moderate Intensity Running Exercise
per
Fasa University of Medical Sciences
Journal of Advanced Biomedical Sciences
2228-5105
2783-1523
2015-08
5
2
289
295
article
Detection of single Nucleotide Polymorphism E326K of SHBG Gene in Breast Cancer of Iranian Females
nastaran haghighi
1
ztahmasebifard@yahoo.com
2
nahid nafisi
3
Department of Biology, Islamic Azad University, Roudehen Branch, Roudehen, Iran.
Department of Biology, Islamic Azad University, Roudehen Branch, Roudehen, Iran. 3- Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Background & Objective: Sex Hormone-Binding Globulin (SHBG) is a plasma glycoprotein that regulates the action of steroid hormones on several levels. Since SHBG is one of the growth regulators of breast cancer cells, the aim of this study was to evaluate the association between polymorphisms E326K and the risk of breast cancer.
Materials & Methods: This study was done as a case-control study on 79 patients with breast cancer and on 79 healthy women who had gone to Shohada-e Tajrish Hospital in Tehran. The average age of patients and control subjects were 48 -+ 8 and 43 -+ 6 years, respectively. After blood sampling and DNA extraction, genotyping of all samples were determined by PCR-RFLP method and the results were statistically analyzed using SPSS 19 software.
Results: After counting the genotypes, their percentages in the cancerous specimens and control group were AA (56.9%), GG (35.4%), AG / GA (7.6%) and AA (12.6%), GG (77.2%), AG / GA (10.1%), respectively. In addition, according to Hardy-Weinberg equilibrium, in cancer patients, the frequency of allele A was 60.7% and the frequency of allele G was 39.2% and in control group the frequency of allele A was approximately 21.5% and the frequency of allele G was calculated 82.3%. Statistically, a significant correlation was observed between the homozygotes of the two groups (P-Value ˂0.05).
Conclusion: The results showed that the E326K polymorphism in exon 8 of SHBG gene is associated with the risk of breast cancer and it may be a factor involved in it.
http://jabs.fums.ac.ir/article-1-702-en.pdf
Polymorphism E326K
Breast cancer
Sex Hormone-Binding Globulin (SHBG)
Gene