Fasa University of Medical Sciences
Journal of Advanced Biomedical Sciences
2228-5105
4
2
2014
9
1
141
142
FA
Abbas
Abdollahi
Elaheh
Ahmadi
Abdolrasol
Zakerin
Because of the absence the specific standards for antibacterial effects evaluation of herbs and challenges in this field, some notes on the main problems in standardization of these procedure have been regarded: the weight of medical herbs according the use of herbs based on the recommendations of the traditional medicine, study on related standard bacteria, applying of essence or herb extract, suitable extraction method, type of solvent in extraction, the time of harvesting plant and confirmed by an expert in herb, reliable methods of microbiological research and drug sensitivity, and finally, use of standard antimicrobial drugs as a benchmark to compare
Fasa University of Medical Sciences
Journal of Advanced Biomedical Sciences
2228-5105
4
2
2014
9
1
Gene Family: Structure, Organization and Evolution
143
153
FA
Mohammad Hossein
Mehraban
Department of Biology, Division of Genetics, University of Isfahan, Isfahan, Iran
Javad
Jamshidi
Department of Biochemistry, Fasa University of Medical Sciences, Fasa, Iran
Sadeq
Vallian
Department of Biology, Division of Genetics, University of Isfahan, Isfahan, Iran
Gene families are considered as groups of homologous genes which they share very similar sequences and they may have identical functions. Members of gene families may be found in tandem repeats or interspersed through the genome. These sequences are copies of the ancestral genes which have underwent changes. The multiple copies of each gene in a family were constructed based on gene duplications and reverse transcription in the genome, which in turn, would give rise to gene variability in an individual or population. Furthermore, it would provide the cell`s vital demands for duplication, transcription, and translation. Differences in family size due to gene duplication and gene loss in cell-specific lineages may provide insights of evolutionary forces that have shaped the mammalian genome. Positive selection and concerted evolution are the main forces and the original candidates of shaping gene families and their larger partner, gene superfamily.
Fasa University of Medical Sciences
Journal of Advanced Biomedical Sciences
2228-5105
4
2
2014
9
1
Immunogenicity of Hepatitis B Vaccine among Medical Staff of Shahid Madani Hospital of Tabriz, Iran
154
160
FA
Mehrdad
Asghari Estiar
Students' Scientific Research Center, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Reza
Moaddab
Department of Laboratory Sciences, Paramedical Faculty, Tabriz University of Medical Sciences, Tabriz, Iran.
Nima
Esmaeelnasab
Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Abdolnaser
Rafi
Department of Laboratory Sciences, Paramedical Faculty, Tabriz University of Medical Sciences, Tabriz, Iran.
Background
; Objectives:
Vaccination is one of the best methods of prevention against hepatitis B virus.
With respect to various vaccines against this virus and based on the
differences of selected factors of immunogenicity, various studies on different
groups in different locations is necessary. In present research, therefore the
titer amount value of antibody against surface antigen of hepatitis B virus
(anti-HBs) was determined and its relation with different factors among medical
staff was investigated.
Materials
; Methods:
This study is descriptive observational, retrospective which is conducted using
questionnaire and serology tests. 146 persons of medical staff of Shahid Madani
Hospital of Tabriz, Iran were the population. The sample size was selected
based on the high risk group. Anti-HBs value was measured based on ELISA
method.
Results: Out of 146 subjects, 32 persons (24%) had
no protective titers (anti-HBs<10 MIU/ML), 38 persons (25.3%) had relative
protective titers (10≤anti-HBs≤100 MIU/ML), and 76 persons (50.7%) had
complete protective titers
(anti-HBs>10 MIU/ML). It was indicated that there was a significant relation
between antibody titer and age, smoking, and the injection of full dose of vaccine
(p0.05).
Conclusion: Since the medical staff
is in the high risk group, full training and vaccination is recommended and
their anti-HBs should be analyzed annually and if necessary, revaccination in
older ones should be done.
Fasa University of Medical Sciences
Journal of Advanced Biomedical Sciences
2228-5105
4
2
2014
9
1
Investigating Different Factors of Fear in Normal Delivery among Pregnant Women, in Arak -A Cross Sectional Study
161
167
FA
Mahboubeh
Khorsandi
Health Department, Arak University of Medical Science, Arak, Iran
Katayon
Vakilian
Nursing Midwifery School, Arak University of Medical Science, Arak, Iran
Mona
Nasir zadeh Masooleh
Arak University of Medical Science, Arak, Iran
Background
; Objective: This study was
designed to investigate the causes
and factors related to natural childbirth among pregnant women who attended prenatal care of Arak.
Materials & Methods: This
cross-sectional study was carried out among
595 women who attended to prenatal care of Arak. Five hospitals were selected
randomly. Only the pregnant women who wish to complete the questionnaire were
enrolled in the study. The data were analyzed using chi-square test, t-test,
the Mann-Whitney –u test, x2, Friedman Test through SPSS16 software.
Results: The average sample age was 26 ±5.3 years. The mean score for nulliparous
women on the Fear of Childbirth Questionnaire (26.2 ± 7.8) was significantly
higher than that of multiparous women (23.9 ± 7.9), p<0.0 01. There was a significant difference between the scores
of childbirth, women who chose the caesarian 27.5 ±5.1 and the women who chose natural childbirth 24.1±3.2
p= (0.02). The results indicated that the most common cause of fear was of the possible harm to the baby 77.9% (459).
Conclusion: As far as the women’s fear regarding child birth were
mostly higher among nulliparous and cesarean women, it is recommended to make
them aware about the causes of fear and provide consulting services in order to
reduce the demand of caesarean as a way of childbirth.
Fasa University of Medical Sciences
Journal of Advanced Biomedical Sciences
2228-5105
4
2
2014
9
1
Comparing Home-based Pulmonary Rehabilitation Nursing on Fatigue and quality of life in Patients with COPD
168
176
FA
Zeynab
Jokar
Bushehr University of Medical Sciences, Bushehr, Iran
Farahnaz
Mohammadi
Iranian Research Center on Aging, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
Hamid Reza
Khankeh
Nursing Department, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
Saeid
Fallah Tafti
Nursing and Respiratory Health Management Research Center, NRITDL, Masih Daneshvari, Hospital Shahid Beheshti University of Medical Sciences,Tehran, Iran
Faramarz
Koushesh
Bushehr University of Medical Sciences, Bushehr, Iran
Background & Objective:The aim of the present study is to compare the
effects of home-based pulmonary rehabilitation nursing care on Fatigue and QOL in
patients with COPD.
Materials & Methods: This study was a semi experimental research. The samples
were consisted of 36 patients who were selected based on inclusion and
exclusion criteria into control and experimental groups through random block
sampling. For each of the experimental group 3 sessions of 1 hour raining over
three consecutive days were done individually and it continuous up to 7 days
after the patients discharged from the hospital. However, the control group was
under the regular manner. Fatigue and quality
of life in both groups before the intervention and 7
weeks after discharge using the Fatigue Severity Scale (FSS) and quality of
life questionnaire SF-12 were
compared. The data were analyzed through
inferential and descriptive statistic (Independent and paired t-test, chi-square
and covariance analysis).
Results: Eta squared
values obtained in this experiment also showed that the effect
of home-based pulmonary rehabilitation program on fatigue (89%) is greater than the
quality of life (50%), respectively.
Conclusion: As the findings indicate, the effect of home-based pulmonary
rehabilitation nursing care, which has the decreasing factor on fatigue is more
than the quality of life in patients
with COPD.
Fasa University of Medical Sciences
Journal of Advanced Biomedical Sciences
2228-5105
4
2
2014
9
1
he Prevalence of Human Intestinal Parasites in Rural Areas of Saveh, Markazi Province, Iran
177
184
FA
Ali Ehsan
Shahbazi
Department of Medical Parasitology & Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
Mostafa
Rezaeian
Department of Medical Parasitology & Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
Mohammad Reza
Eshraghian
Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
Mahdi
Mohebali
Department of Medical Parasitology & Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
Mohammad Bagher
Rokni
Department of Medical Parasitology & Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
Meysam
Sharifdini
Department of Medical Parasitology & Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
Eshrat Beygoam
Kia
Department of Medical Parasitology & Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
Background & Objective: As far as no study has been done on the prevalence
of parasitic infections in Saveh, Markazi Province, Iran, the current study aimed
to investigate the prevalence of intestinal parasitic infections in rural areas
of Saveh during 2005-2006.
Materials & Methods: 755 people were selected and examined randomly
through systematic cluster sampling for intestinal parasites using formalin
ether sedimentation technique, as well as direct smear for the diarrheic
samples.
Results: In general, 14% of individuals were infected with
intestinal parasites. The rate of infection with protozoa and helminth
parasites were 13.3% and 0.7%, respectively. The infection rate of each
parasite species were as follows: Entamoeba coli 5.9%, Giardia
lamblia 5.6%, Blastocystis hominis 1.6%, Iodamoeba butchli
0.1%, Chilomastix mesnili 0.1%, Hymenolepis nana 0.3%, Enterobius
vermicularis 0.3% and Taenia 0.1%.
Conclusion: Comparing the prevalence of intestinal parasites in other parts of the
country, especially the rural areas, it is found that the prevalence was lower in
Saveh, which is prominent for helminthes parasites. Considering that Saveh is known as a healthy city, the efficient health services in
this area is concluded from the obtained results. Therefore, providing treated
safe water and sanitation for the reduction of parasites, especially Giardia are recommended in the study area.
Fasa University of Medical Sciences
Journal of Advanced Biomedical Sciences
2228-5105
4
2
2014
9
1
Designing an Intelligent, Non-Contact System for Controlling Neonate’s Body Temperature in Incubators
185
193
FA
Behrouz
Moradhasel
Department of Biomedical Engineering, Kermanshah University of Medical Sciences, Kermanshah, Iran
Mostafa
Taghipour
Department of Biomedical Engineering, Kermanshah University of Medical Sciences, Kermanshah, Iran
Masumeh
Seidi
Department of Biomedical Engineering, Kermanshah University of Medical Sciences, Kermanshah, Iran
Vahab
Dehlaghi
Medical education development center, Hamedan University of Medical Sciences, Hamedan, Iran
Sajad
Pashotan shayesteh
Department of Medical physics, Kermanshah University of Medical Sciences, Kermanshah, Iran
Background
and Objective: Regulating body temperature
of premature infants and preparing them a desirable physical condition for
completing physical and mental development is essential. Using a system that
guarantees neonate’s health in incubator at first birth hours is cardinal.
Materials
and Methods: In this method, a set of non-contact infrared sensors
and microcontrollers regulate neonate’s body temperature without skin sensor.
Temperatures were converted to digital data after mean evaluation. They were
sent to digital microcontroller for user's settings and functional orders of
internal conversion system of incubator.
Results: In
this study, an intelligent system is presented for controlling body temperature
of premature infants in incubators without skin sensors.
Conclusion: This
technique causes incubator’s proper performance and safety. It prevents damages
to brain and other organs of premature neonates and reduces neurological
disorders of these infants.
Fasa University of Medical Sciences
Journal of Advanced Biomedical Sciences
2228-5105
4
2
2014
9
1
Comparing the Amount of 25-Hydroxy Vitamin D3 Concentrated in Serum of Normal and Overweight/ Obese Women and Its Relation to Metabolic Syndrome
194
200
FA
farzad
roshanzamer
Department of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran, Fasa University of Medical Sciences, Fasa, Iran.
Homeyra
Hamayeli Mehrabani
Fasa University of Medical Sciences, Fasa, Iran.
Mohammad Hasan
Meshkibaf
Fasa University of Medical Sciences, Fasa, Iran.
Mahdi
Mahmoodi
Department of Biochemistry and Biophisics, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
Rezvan
Bizhani
Fasa University of Medical Sciences, Fasa, Iran.
Alireza
Khorshid
Tarbiat Modares University, Tehran, Iran
Background ;
Objective: The relationship between vitamin D3
and risk factors of metabolic syndrome is unclear. This study aimed to
investigate the vitamin D3 kevel of women and its relation with
metabolic syndrome risk factors.
Materials & methods: A cross-sectional study
conducted between 200 healthy women aged 20 to 50 in two groups of normal BMI
(BMI=18.5-24.9 kg/m2) and overweight/obese group (BMI≥25 kg/m2)
who did not use mineral and vitamin supplementation. A fasting blood sample
after 10 to 12 hour collected for fasting blood glucose, triglyceride,
HDL-cholesterol and vitamin D3(25 OH D3) and weight,
height, waist circumference, systolic and diastolic blood pressure were
measured.
Results: The mean of 89 obese subjects and 76 normal
weight ones were 36±9 years old. The mean of 25 hydroxy vitamin D3
was not significantly different between the two groups 22.3±19.9 ng/ml for
normal weight group and 16.5±11.4 ng/ml for the obese one (p=0.31).
HDL-cholesterol (r=.25, p<0.05) and waist circumference (r=-.14, p<0.05)
were related to vitamin D3 levels significantly which repeated after
BMI (body mass index) adjustment
Conclusion: The results indicated that although the total amount
of vitamin D3 were not significantly different between the two groups but more
than 80 percent of women in both groups were deficient in vitamin D3 which is a
noteworthy issue based on the findings
of the study.
Fasa University of Medical Sciences
Journal of Advanced Biomedical Sciences
2228-5105
4
2
2014
9
1
Determining the Amount of Histamine Levels in Canned Tuna Fish Marketed in Supermarkets of Tabriz City
201
208
FA
Javad
Mohtadi nia
Department of Food Sciences and Technology, Faculty of Health and Nutrition, Tabriz University of Medical sciences, Tabriz, Iran.
Mehrnoush
Zakerzadeh
Department of Nutrition, School of Paramedical, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran
Mehdi
Goudarzi
Department of Pharmacology and Toxicology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Hossein
Rahman pour
Department of Food Sciences and Technology, Faculty of Health and Nutrition, Tabriz University of Medical sciences, Tabriz, Iran.
Hossein
Khadem Haghighian
Department of Nutrition, School of Paramedical, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran
Background & Objective: Histamine poisoning which is induced from seafood is
the most common disease around the world. Determining the amount of histamine in
canned tuna fish shows not only the healthy quality of fish, but also it is
effective in protecting the health and safety of the consumers.
Materials & Methods: In this cross-sectional study, 60 samples of histamine
content canned tuna fish marketed in supermarkets of Tabriz city was analyzed through ELISA
method. Histamine levels in the samples were compared based on the time between
the production and the production seasonwith limited range. Statistical analysis
was performed using SPSS software version 16.
Results: Histamine levels between 5-200.3 mg/kg were different.
Histamine levelin canned food was 30 % lower and 70% higher than the
permissible limit (50 mg kg) in some cans. Histamine levels in canned tuna
produced in North and South regions were statistically significant
(p<0.05).Canned tuna fish produced in summer and autumn, respectively, had
the highest and lowest levels of histamine.
Conclusion: According to high percentage of canned tuna, which
have histamine more than permissible limit, the risk of histamine toxicity is
there for consumers of such kind of food.
Fasa University of Medical Sciences
Journal of Advanced Biomedical Sciences
2228-5105
4
2
2014
9
1
Surveying the Contamination Rate, Sensibility and Antimicrobial Resistance Patterns in Staphylococcus Aureus Isolated from Traditional Cheese Consumed in Qotur of khoy Province
209
217
FA
Hamed
Molla Abaszadeh
Islamic Azad University of Marand, Department of Microbiology, Mrand, Iran
Begnood
Haji Sheikhzadeh
Islamic Azad University of Marand, Department of Microbiology, Mrand, Iran
Background ;
Objective: Milk
and dairy products are good nutritional environments for bacterial growth.
Different types of bacteria can quickly contaminate them and as a result, these
products cause disease in human after transmission. Staphylococcus aureus
is among the bacteria of milk and dairy products that cause disease in human.
With regard to the point that traditional cheese(unpasteurized) is produced in
not a sanitary situation among the residents of border and rural areas of
northwest of Iran, the objective of this study was to evaluate the
contamination rate, sensibility and antimicrobial resistance patterns in Staphylococcus
aureus isolated from traditional cheese consumed in Qotur of khoy province.
Materials & Methods: This cross-sectional
study was performed on 80 cheese samples provided from different dairy products
stores of Qotur town in Khoy city during in the first six months of the year
2011. After collecting the samples, they were transported to the laboratory.
Results: among 80
studied samples, 16 samples (20%), 40 samples (50%), and24 samples (30%) were
produced from cow milk, sheep milk, and a mixture of cow and sheep milk,
respectively. 40 samples (50%) showed contamination by Staphylococcus aureus.
Antibiotic resistances to Methicillin, Tetracycline and Cotrimoxazole, and
Oxacilina were seen in four samples (9.3%), two samples (4.65%), and one sample
(2.33%), respectively.
Conclusion: Considering the high
contamination rate of traditional cheese by Staphylococcus aureus in this
area, respective experts should control its production and distribution. Efficient informing about the risk of using
these products seems necessary.
Fasa University of Medical Sciences
Journal of Advanced Biomedical Sciences
2228-5105
4
2
2014
9
1
Evaluation of Demografic and clinical characters of patients whit Bacterial vaginosis in Ahwaz Amir Almoomenin hospital.
218
224
FA
Fatemeh
Goodarzi
Yasuj University of Medical Sciences, Yasuj, Iran
Marziyeh
Hosseini
Yasuj University of Medical Sciences, Yasuj, Iran
Fatemeh
Hekmat zadeh
Yasuj University of Medical Sciences, Yasuj, Iran
Background & Objective: Bacterial vaginosis is the most
common cause of vaginitis among women of reproductive ages. This study
evaluated demographic and clinical characteristics of patients with
bacterial vaginosis to help diagnosis of patients referring to Ahvaz Amir
Almoomenin hospital.
Materials & Methods: In this descriptive cross-sectional
study, 120 non-pregnant
women of 15-45 years in reproductive ages referring to Ahwaz Amir
Almoomenin hospital were
included after confirmed diagnosis of bacterial vaginosis based on Amsel
criteria. Descriptive statistics (mean and standard deviation) were used for
data analysis.
Results: 120 women with bacterial vaginosis
were studied. The mean age for bacterial vaginosis was 31.3 years. 68.3% had
sexual activity before 20 years. Their most common complaints were malodor
discharge (60%) and increased vaginal discharge (33.3%). Whiff test was
positive in 95.83% of patients. More than 20% of clue cells were in 96.6% of
them.. The discharge PH was greater than or equal to 4.5.
Conclusion: The patiensts most common
complaints were malodor discharge and increased vaginal discharge,
respectively. These symptoms help widely to diagnose bacterial vaginosis
besides vaginal discharge PH and whiff test.
Fasa University of Medical Sciences
Journal of Advanced Biomedical Sciences
2228-5105
4
2
2014
9
1
Comparing the Effect of Breast-Feeding and Oral Glucose on Infants Vaccination Pain
225
232
FA
Leila
Nikrouz
Nursing department, Fasa University of Medical Sciences, Fasa, Iran
Shahnaz
Rostami
Nursery and Midwifery department, Jundishapur University of Medical Sciences, Ahvaz, Iran
Houshang
Alijani Renani
Nursery and Midwifery department, Jundishapur University of Medical Sciences, Ahvaz, Iran
Abdolrahman
Rasekh
Department of mathematics and computer science, Shahid Chamran University, Ahvaz, Iran
Mohammad Mehdi
Naghizadeh
Department of community medicine and statistics, Fasa University of Medical Sciences, Fasa, Iran
Background and Objective: Ignoring pain especially in infancy causes serious complications. Considering recent studies about
sedative effect of breast-feeding and oral glucose on neonates, this study was
performed to survey each method after neonatal period.
Materials and Methods: This study is a triple blind clinical trial on 211 infants aged 2, 4,and 6 months, which were randomly categorized into
control, breast-fed, and oral glucose groups. Interventions were performed two minutes before
injecting DPT vaccine. The infants’ reactions were recorded before,
during, and after intervention. Two experts evaluated pain intensity by Modified
Behavioral Pain Scale (MBPS). The
crying duration was measure by chronometer in second.
Results:
Pain intensities for breast-fed, oral glucose, and control groups were
5.77±0.18, 6.63±0.16, and 5.87±0.22, respectively. Least
Significant Difference (LSD) test showed that MBPS was significantly lower in breast-fed compared to oral glucose
group (P value=0.014). The difference between breast-fed and
control groups was not significant. Crying duration did
not have significant difference among the three groups.
Conclusion: It seems that breast-feeding has
better effect on vaccination pain compared to oral glucose.
Fasa University of Medical Sciences
Journal of Advanced Biomedical Sciences
2228-5105
4
2
2014
9
1
Investigation of KCNJ11 Gene Variant (rs 5219) in Patients with Diabetes after Liver Transplantation
233
242
FA
Zahra
Parvizi
Department of Biology, Arsanjan Branch, Islamic Azad University, Arsanjan, Iran
Negar
Azarpira
Transplant Research Center, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
Leila
Kohan
Department of Biology, Arsanjan Branch, Islamic Azad University, Arsanjan, Iran
Kurosh
Kazemi
Transplant Ward, Shiraz University of Medical Sciences, Shiraz, Iran
Mohammad mahdi
Parvizi
Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Background & Objective: The incidence of diabetes in liver
transplant recipients is one of the common problems among these patients witha
negative effect on the success of the transplant and the patient's life. Post
Transplant Diabetes Mellitus (PTDM) has
many similarities with type 2 diabetes from pathophysiplogical, clinical, and
genetic viewpoints... One of the genotypes involved in PTDM is KCNJ11 (rs 5219) that has role in beta-cell function and has
regulator effect on ATP sensitive K channels. The purpose of this study is to
review the relation between this polymorphism and diabetes after liver
transplantation in an Iranian population.Materials ; Methods: This is a case-control study on 120 patients receiving liver
transplant, including 60 patients with PTDM and 60 patients without PTDM.
White blood cell samples were selected from
the cell bank of organ transplantation research centre in Namazi Hospital from
patients who had undergone liver transplantation during the years 2008 and2012.
Frequency of genotypes in this population was determined by PCR-RFLP method. To express
the results we used distribution indices and parametric statistical tests.Results: Statistical analysis shows that there is a significant difference
between the genotype and the allele frequencies of the two groups of case and
control.. KK genotype (P=0.001 95%CI (1.60-7.6) OR=1.19 increases the risk of
PTDM.
Conclusion: Our study shows that there
is a relation between the incidence of PTDM and sex, age, prednisolone dosage,
KCNJ11 polymorphism, and KK genotype.
Fasa University of Medical Sciences
Journal of Advanced Biomedical Sciences
2228-5105
4
2
2014
9
1
Evaluation of Mexiletine Effect on Bispectral Index Changes and Hemodynamic Responses to Endotracheal Intubation and During General Anesthesia
243
250
FA
mohammad ali
haghbin
Department of Anesthesiology, Neurology Research Center, Kerman University Of Medical Science, Kerman, Iran
hamid
khosro zamiri
Department of Anesthesiology, Kerman University of Medical Science, Kerman, Iran
marjan
shahabi
Department of Anesthesiology, Kerman University of Medical Science, Kerman, Iran
mohammad
shabani
Neuroscience Research Center, Neuropharmacology Institute, Kerman University of Medical Science, Kerman, Iran
hamed
vahdani
Kerman Health Center, Kerman University of Medical Science, Kerman, Iran
Background ;Objective: Plaryngoscopy and
tracheal intubation increase not only blood pressure and heart rate but also
Bispectral Index (BIS) of the patients. In this study, hemodynamic and BIS changes were surveyed after tracheal intubation and
during general anesthesia followed by mexiletine prescription .
Materials & Methods: In this study, 50
patients aged between 20 and 60 who were candidates for orthopedic surgery of
the upper limbs were surveyed. They were divided in two groups randomly. Two
hours before induction of anesthesia, case
and control groups received mexiletine 200 mg as capsule and oral placebo,
respectively. Systolic and diastolic blood pressures ,heart rate,
and BIS of both groups were compared before induction and intubation 1,3 and
10 minutes after intubation and immediately
, 15, 30, 45, and 60 minutes
after surgical incision.
Results: There was not any significant differences in systolic and
diastolic pressures of the two groups. The heart rate was lower in mexiletine group
compared to control group, 30 minutes after surgical incision and immediately
after extubation (P<0.05). BIS
was significantly more in mexiletine groupcompared to control group
(p<0/05).
Conclusion: It was revealed that
the hemodynamic changes after laryngoscopy and during general anesthesia
were significantly lower in mexiletine group compared to the control group. It`s suggested that the prescription
of this drug leads to the increase of BIS after intubation and during general
anesthesia.
Fasa University of Medical Sciences
Journal of Advanced Biomedical Sciences
2228-5105
4
2
2014
9
1
Evaluating the Effect of Vitamins E and C on Sexual Cell Lineages in Adult Male Rats under Oxidative Stress Induced by Endosulfan Consumption
250
257
FA
yazdan
heydari
Department of Biology, Payamnoor University, Bavanat Branch, Fars, Iran.
shirzad
hosseini
Department of Anatomy, School of Medicine Tehran, University of Medical Sciences, Tehran, Iran.
mojtaba
keshavarz
Young Researchers and Elite Club, Shiraz Branch, Islamic Azad University, Shiraz, Iran.
ahmad
mozafar
Young Researchers and Elite Club, Science and Research Branch, Islamic Azad University, Fars, Iran.
mohammadhasaan
meshkibaf
Department of Biochemistry, Fasa University of Medical Sciences, Fasa, Iran.
mohammadali
takhshid
Diagnostic Laboratory Sciences and Technology Research Center, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
Background ;
Objective: Endosulfan is one of the strong insecticides used in agriculture.
This toxin is absorbed by inhalation and skin. Endosulfan has side effects such
as infertility in men. This study surveys the effect of vitamins E and C
on preventing the harmful effects of
Endosulfan on spermatogenesis in adult male rats.
Materials ;
Methods: Adult male rats (200-250 g) from Wistar rats were divided into
five groups of 10 rats. Rats in the
experimental groups one, two, three, and four received 10 mg/kg Endosulfan
daily for 10 consecutive days via gavage. Moreover, during this period, rats of
group two in addition to daily Endosulfan,
received 20 mg / kg vitamin C daily, group three received 200mg / kg Vitamin E
daily and group four received20mg / kg kg vitamin C plus 200mg / kg Vitamin E
daily, by gavage. Control group received only routine food and water. At the
end of this period, sexual cells were counted by light microscope on testis
sections. The results were analyzed by
one-way ANOVA test and Duncan's test at p≤0.05.
Results: The
results showed that vitamins E and C have inhibitory effect on the degenerative
impact of Endosulfan on spermatogenesis.
Conclusion: The
results of this study indicated that Endosulfan impairs spermatogenesis by
increasing the oxidative stress. Vitamins E and C inhibit the degenerative
effects of Endosulfan on spermatogenesis by reducing the oxidative stress.