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:: Volume 2, Issue 4 (Winter 2013) ::
J Fasa Univ Med Sci 2013, 2(4): 287-297 Back to browse issues page
The Effect of Ecstasy (MDMA) on the Number of Ovary Follicles and Hormonal Axis of Pituitary-Gonadal in Immature Rats
Zahra Allaeian, Vahid Hemayatkhah Jahromi 1, Houshang Jamali, Hosein Kargar Jahromi, Ali Reza Allaeian Jahromi
1- , Dr.hemayatkhah@yahoo.com
Abstract:   (30230 Views)

Background & Objective: The widespread use of the pills of ecstasy has opened the floodgates to social damage. Severe kidney and liver damage as well amnesia and imbalance are some of ecstasy pills complications. This study evaluated the effect of these pills on the ovary and hormonal axis of pituitary-gonadal axis in rats.


Materials & Methods: Thirty-five female immature Wistar rats were divided into 5 groups of 7 rats, comprising control, sham, experimental 1, experimental 2, and experimental 3 groups. The control group did not receive any solvent or medication the sham group received physiologic serum (0.2 cc) once daily for 14 days and the experimental groups of 1, 2, and 3 received a solution (0.2 cc) once daily containing 0.5, 1, and 2 mg of medication for 14 days via intraperitoneal injection. Hormone measurement was done with the ELISA method. Ovaries were excised to prepare tissue sections and to investigate the number of ovarian follicles. The number of follicles was calculated via the physical dissector technique.


Results: There was a statistically significant difference in body and ovary weight between the control group and the experimental group 3. Also, the number of primary and Graafian follicles decreased significantly. The results did not show a statistically significant difference between the three experimental groups and the control group in terms of FSH and LH hormones, but the rate of progesterone hormone had a meaningful increase.


Conclusion: Use of ecstasy pills exerted a destructive impact on the ovary and progesterone hormone.

Keywords: Ecstasy, Ovary, LH, FSH, Progesterone, Rat
Full-Text [PDF 1653 kb]   (8050 Downloads)    
Type of Study: Research | Subject: Physiology
Received: 2013/03/13 | Accepted: 2013/09/14 | Published: 2013/09/14
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Allaeian Z, Hemayatkhah Jahromi V, Jamali H, Kargar Jahromi H, Allaeian Jahromi A R. The Effect of Ecstasy (MDMA) on the Number of Ovary Follicles and Hormonal Axis of Pituitary-Gonadal in Immature Rats. J Fasa Univ Med Sci. 2013; 2 (4) :287-297
URL: http://jabs.fums.ac.ir/article-1-146-en.html

Volume 2, Issue 4 (Winter 2013) Back to browse issues page
Journal of Fasa University of Medical Sciences
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