[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Submit :: Indexing :: Contact Us ::
:: Volume 12, Issue 1 (Winter(2022) 2022) ::
JABS 2022, 12(1): 60-68 Back to browse issues page
The Effect of Simvastatin and Vitamin D Co-Administration on Rats Brain Function and Behavior: A Behavioral and Biochemical Study
Mohammad Saleh Ranaiy1 , Farah Farokhi 2, Farrin Babaei Balderlou1
1- Department of Biology, Faculty of Sciences, Urmia University, Urmia, Iran
2- Department of Biology, Faculty of Sciences, Urmia University, Urmia, Iran , f.farokhi@urmia.ac.ir
Abstract:   (2841 Views)
Background & Objective: The simvastatin (Sim) is a lipophilic statin and can cross the blood-brain barrier. The role of vitamin D (Vit D) in brain development and function has been supported over the past decade. This study aimed to evaluate the effect of simvastatin on memory and anxiety levels in healthy male rats.
Materials & Methods: In this experimental study, 36 male Wistar rats weighing 250-300 g were randomly divided into six groups (n=6) including control, Vit D (5 µg/kg/day; IP), Simvastatin (1 mg/kg/day; orally) (SimL), Simvastatin (10 mg/kg/day; orally) (SimH), SimL + Vit D and SimH + Vit D. After 28 days, at the end of the treatment, the behavioral anxiety test and memory behavioral test were performed. Then, the rats were euthanized, and oxidative stress markers of the brain, serum low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and cholesterol levels were investigated. Data were analyzed by SPSS 24 software and Tukey’s test.
Results: Co-administration of simvastatin and vitamin D significantly increased working memory, catalase activity, total antioxidant capacity, HDL-C, and decreased anxiety levels, malondialdehyde (MDA) concentration, cholesterol, and LDL-C compared to the control group (p<0.05). However, the administration of simvastatin and vitamin D alone did not significantly change the mentioned parameters compared to the control group (p>0.05).
Conclusion: Co-administration of simvastatin and vitamin D can improve brain function by reducing oxidative stress and cholesterol levels.
 
Keywords: Anxiety, Simvastatin, Vitamin D, Working memory, Rat
Full-Text [PDF 384 kb]   (208 Downloads)    
Type of Study: Research | Subject: Physiology
Received: 2021/09/23 | Accepted: 2022/01/25 | Published: 2022/04/13
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Ranaiy M S, Farokhi F, Babaei Balderlou F. The Effect of Simvastatin and Vitamin D Co-Administration on Rats Brain Function and Behavior: A Behavioral and Biochemical Study. JABS. 2022; 12 (1) :60-68
URL: http://jabs.fums.ac.ir/article-1-2718-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 12, Issue 1 (Winter(2022) 2022) Back to browse issues page
Journal of Advanced Biomedical Sciences
Persian site map - English site map - Created in 0.04 seconds with 29 queries by YEKTAWEB 4457