:: Volume 8, Issue 4 (Winter 2019) ::
JABS 2019, 8(4): 1079-1087 Back to browse issues page
The Survey of relationship between Serum Resistin Level and Metabolic Syndrome Components in patients with and without this syndrome in Rafsanjan (2015)
Farzad Roostaee1 , Shima Zanganeh1, Mohammad Reza Shafiepour1, Mehdi Mahmoudi2, Alireza Khoshdel3, Mohammad Reza Hajizadeh 4
1- Dept. of Clinical Biochemistry, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
2- Molecular Medicine Research Center and Dept. of Clinical Biochemistry, Rafsanjan University of Medical
3- University of Medical Sciences, Rafsanjan
4- University of Medical Sciences, Rafsanjan , hajizadehus@yahoo.com
Abstract:   (3054 Views)

Background &Objective: Resistin is an adipokin secreted from adipose tissue and immunity cells. Relationship between resistin and metabolic syndrome and its components is controversial. The aim of this study is measurement of serum resistin level, insulin resistance and other factors in subjects with and without metabolic syndrome.
Materials & Methods: this cross-sectional study was conducted in 2015, 56 availableperson including; 31subjects were enrolled as the study group and 25 subjects were recruited as the control group of the study. Serum resistin concentrations were measured by ELISA and its association with metabolic syndrome markers was measured. Data were Analyzed using independent T test, Pearson correlation Test and, Chi-squared Test
Results: Serum resistin levels were significantly higher in the metabolic syndrome subject compared with control group (p-value=0.002). Correlation analysis revealed body mass index (p=0.018; r=0.480), waist circumference (p=0.015; r=0.431), systolic blood pressure (p=0.008; r=0.467), diastolic blood pressure (p=0.001; r=0.562), cholesterol (p=0.018; r=0.421) and LDL (p=0.003; r=0.515) were positively correlated with plasma resistin.
Conclusion: Serum resistin levels are elevated in subjects with metabolic syndrome and are associated with some of its components in metabolic syndrome patients, resistin may be associated with the severity of this syndrome and its complications.

Keywords: Resistin, metabolic syndrome, Insulin Resistance
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Type of Study: Research | Subject: Biochemistry
Received: 2017/11/10 | Accepted: 2018/01/15 | Published: 2019/03/17

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Volume 8, Issue 4 (Winter 2019) Back to browse issues page