[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Submit :: Contact Us ::
:: Volume 2, Issue 4 (Winter 2013) ::
J Fasa Univ Med Sci 2013, 2(4): 288-296 Back to browse issues page
Diet-induced metabolic syndrome model in rats
Reza Homayounfar, Elham Ehrampoush, Seyyed Amin Koohpaye, Mohammad Hasan Meshkibaf, Saeid Taghizade, Amin Almasi, Behnam Shahsavani, Hamid Zand
Abstract:   (24571 Views)

Background & Objective: Risk for heart disease, diabetes, and stroke increases with the number of the metabolic risk factors. In general, a person who has the metabolic syndrome is twice as likely to develop heart disease and five times as likely to develop diabetes as someone who does not have the metabolic syndrome. High-calorie-diet rodent models have contributed significantly to the analysis of the pathophysiology of the metabolic syndrome, but their phenotype varies distinctly between different studies and maybe is not very similar to a model of the metabolic syndrome in humans. We sought to create a model in this study close to the disease in humans.


Materials & Methods: Twenty male, Wistar rats were randomly assigned to the high-calorie diet group with 416 calories per 100 grams (researcher made) or the control diet group for 12 weeks. Weight changes, lipid profile, glucose, insulin levels, and QUICKI index (an indicator of insulin sensitivity) were measured. Weight changes were compared using the repeated measures and the independent t-test, and serum factors were compared using the independent t-test.


Results: There was a significant change in weight, glucose, insulin, and lipid profile except for HDL at the end of the study. The QUICKI index (0.34 ± 0.02 vs. 0.40 ± 0.01 p value <0.0001) suggested that insulin resistance had been created in the high-calorie diet group.


Conclusion: The present study demonstrates the ability to make diet-induced metabolic syndrome domestically.

Keywords: Metabolic syndrome, Diet, High-calorie diet, High-fat diet, Wistar rat
Full-Text [PDF 785 kb]   (6684 Downloads)    
Type of Study: Research | Subject: Nutrition
Received: 2013/03/13 | Accepted: 2013/09/14 | Published: 2013/09/14
Add your comments about this article
Your username or Email:


XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Homayounfar R, Ehrampoush E, Koohpaye S A, Meshkibaf M H, Taghizade S, Almasi A, et al . Diet-induced metabolic syndrome model in rats. J Fasa Univ Med Sci. 2013; 2 (4) :288-296
URL: http://jabs.fums.ac.ir/article-1-147-en.html

Volume 2, Issue 4 (Winter 2013) Back to browse issues page
Journal of Fasa University of Medical Sciences
Persian site map - English site map - Created in 0.04 seconds with 30 queries by YEKTAWEB 4319