:: Volume 10, Issue 2 (Summer 2020) ::
J Fasa Univ Med Sci 2020, 10(2): 2179-2185 Back to browse issues page
Evaluation of Nitric Oxide and Interleukin-17 in the Serum of Men During the Fast of Ramadan
Hamideh Mozafari1 , Mohammad Mehdi Eftekharian2 , Ghodratollah Roshanaei3 , Mohammad Reza Safari4 , Gholamreza Shafiee 5
1- Department of Anesthesiology, Faculty of Allied Medical Sciences, Hamadan University of Medical Sciences, Hamadan, Iran
2- Department of Immunology, Neurophysiology Research Center, Institute of Mental Health and Addiction, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
3- Department of Biostatistics, Modeling of Noncommunicable Diseases Research Center, Institute of Health Sciences and Technology Research, Faculty of Health, Hamadan University of Medical Sciences, Hamadan, Iran
4- Department of Laboratory Sciences, Faculty of Allied Medical Sciences, Hamadan University of Medical Sciences, Hamadan, Iran
5- Department of Clinical Biochemistry, Nutrition Health Research Center, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran , g.r_shafiee@yahoo.com
Abstract:   (1102 Views)
Background & Objective: Nitric oxide gas is important in regulating blood vessel dilation, and consequently, blood pressure. Nitric oxide is continuously produced by endothelial cells known as a compound that plays an important role in the cardiovascular system.  Also, Interleukin-17 (IL-17) is a pro-inflammatory cytokine that can mediate protective innate immunity to pathogens or contribute to the pathogenesis of inflammatory diseases. In the current study, the plasma levels of nitric oxide and serum level of IL-7 were assessed before and after Ramadan month in fasting people, aimed at the scientific investigation of the possible preventing effects of fasting for cardiovascular disease.
Materials & Methods: The present study 61 fasting man (30-60 years old) were selected and blood samples were collected from each one day before and one day after Ramadan month. Serum levels of Nitric oxide and IL-17 were measured in two groups by ELIZA kits.  
Results: The results of this study shown the serum level of nitric oxide was significantly increased in individuals before and after Ramadan month (from 16.17 ± 1.15 mmol/L to 22.17 ± 1.46 mmol/L, respectively) (P<0.0001). Also, the results indicate that serum level of IL-17 was statistically different in two groups (from 58.25 ± 10.59 pg/ml to 15.98 ± 4.66 pg/ml, respectively) (P<0.0001).
Conclusion: The results of this study showed that nitric oxide and IL-17 levels decreased during the Ramadan month and so it can be concluded the fasting of Ramadan may have positive effects on cardiovascular and immune factors of the body.
 
 
Keywords: Fasting, Interleukin-17, Nitric oxide, Ramadan
Full-Text [PDF 944 kb]   (249 Downloads)    
Type of Study: Research | Subject: Biochemistry
Received: 2020/02/16 | Accepted: 2020/06/29 | Published: 2020/09/19


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Volume 10, Issue 2 (Summer 2020) Back to browse issues page