Journal of Advanced Biomedical Sciences

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ِِِDaneshmandi H, Azamian Jazi A, Ghasemi B. Effects of Eight Weeks of Moderate-Intensity Continuous and Resistance Training on The Glycogen Synthase Kinase-3 Beta Gene Expression, and Serum Glucose and Insulin Levels in Streptozotocin-Induced Diabetic Rats. JABS 2020; 10 (4) :2716-2727
URL: http://jabs.fums.ac.ir/article-1-2368-en.html

Background & Objective: Patients with diabetes have impaired beta cells function and insulin secretion. Exercise training may have a significant role in the improvement of these disorders through the expression of the specific genes. Therefore, the present study aimed to investigate the effects of eight weeks of moderate-intensity continuous and resistance training on the glycogen synthase kinase-3 beta (GSK-3β) gene expression, and serum glucose and insulin levels in streptozotocin-induced diabetic rats
Materials & Methods: 24 rats were divided into four groups: healthy control, diabetic control, diabetic + moderate-intensity continuous training, and diabetic + moderate-intensity resistance training. Diabetes was induced by intravenous injection of 110 mg nicotinamide, and 40 mg streptozotocin per kg of body weight. Exercise training intervention was performed for eight weeks. Expression of GSK-3β gene in pancreatic tissue was measured by real-time PCR, and serum glucose and insulin levels were measured by ELISA. Data were analyzed using one-way analysis of variance.
Results: Insulin levels in the resistance and continuous training groups increased compared to the diabetic control group (p<0.05) and decreased compared to the healthy control group (p<0.05). Also, blood glucose levels in the resistance and continuous training groups decreased compared to the diabetic control group (p<0.05) and increased compared to the healthy control group (p<0.05). Moreover, the results showed a significant decrease in GSK-3β gene expression in the resistance and continuous training groups compared to the healthy control and diabetic control groups (p<0.05).
Conclusion: It seems that insulin secretion can increase through the decrease in GSK-3β expression following the eight weeks of moderate-intensity continuous and resistance training.