:: Volume 5, Issue 2 (Summer 2015) ::
JABS 2015, 5(2): 196-201 Back to browse issues page
Assessment of HCV Infection in Suspected Orphans Newborns by Real-Time PCR and HCV-Core Ag-Elisa
Marzieh Jamalidoust1, Mandana Namayandeh2, Maryam Zare2, Mazyar Ziyaeyan 3
1- Department of Medical Virology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
2- Prof. Alborzi Clinical Microbiology Research Center, Nemazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
3- Prof. Alborzi Clinical Microbiology Research Center, Nemazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran. , ziyaeyanm@sums.ac.ir
Abstract:   (8676 Views)

Background & Objective: HCV infection may be transmitted from an infected mother to her fetus in a low percentage however, it is the most important route of infancy HCV infection. The chance of HCV transmission in HIV/HCV co-infected mothers is higher than that in HCV mono-infected ones. The aim of this study is to assess HCV infection status in orphan newborns in Shiraz, Iran by quantitative PCR assay and HCV core-Ag Elisa.

Materials & Methods:  Twenty nine HCV suspected infants, 2-7 months old, were evaluated for HCV and HIV antibodies, HCV core antigen and quantitative genome viral load.

Results: Although HCV-Ab was detected in all the studied infants, HCV-RNA was not detected in plasma or Peripheral Blood Mono-Nuclear Cells (PBMCs). HIV 1, 2 Abs were not detected in none of them, either.

Conclusion: A few studies have been conducted on the HCV transmission from infected mothers to their infants. According to the present results, assessment of HCV viral load and HCV core-Ag can serve as reliable tests for the prediction or exclusion of HCV infection from mothers to infants.

Keywords: HCV infection, Orphan newborn, Quantitative PCR, HCV-core Ag
Full-Text [PDF 756 kb]   (2785 Downloads)    
Type of Study: Research | Subject: Virology
Received: 2014/11/15 | Accepted: 2015/06/22 | Published: 2015/08/16


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Volume 5, Issue 2 (Summer 2015) Back to browse issues page