TY - JOUR T1 - Evaluation of The Antibacterial Effects of The New Benzothiazole and Tetrahydropyrimidine Derivatives against Streptococcus Iniae, Edwardsiella Tarda and Aeromonas Hydrophila as Some Zoonotic Bacterial Pathogens TT - بررسی اثرات ضد باکتریایی مشتقات جدید بنزوتیازول و تتراهیدروپیریمیدین بر آئروموناس هیدروفیلا، استرپتوکوکوس اینیایی و ادواردزیلا تاردا به عنوان سه باکتری بیماری‌زای مشترک بین آبزیان و انسان JF - JABS JO - JABS VL - 6 IS - 2 UR - http://jabs.fums.ac.ir/article-1-951-en.html Y1 - 2016 SP - 162 EP - 168 KW - Antibacterial KW - Zoonotic Bacteria KW - Benzothiazole and tetrahydropyrimidine N2 - Background & Objective: The novel stronger antibacterial compounds such as the thiazole and pyrimidine derivatives are needed in order to remove the threat of bacterial antibiotic resistance in zoonotic aquatic bacterial pathogens. In this study, we evaluated the inhibitory effect of the new benzothiazole and tetrahydropyrimidine derivatives against three important zoonotic aquatic pathogens including Streptococcus iniae, Edwardsiella tarda and Aeromonas hydrophila. Material & Methods: Benzothiazole and tetrahydropyrimidine derivatives were synthesized and dissolved in DMSO with a concentration of 8129 μg/mL. Then, the disk diffusion and broth microdilution methods were applied to evaluate the antibacterial effects. Results were recorded as the minimum inhibitory concentration (MIC) and the growth inhibition zone diameter. Results: The study showed that the two tetrahydropyrimidine derivatives had no inhibition effects on all of the studied bacteria. Moreover, no inhibitory effect was observed from the three banzothiazole derivatives against A. hydrophila. However, the benzothiazole derivatives showed significant inhibitory effect against S. iniae and E. tarda with MIC of 256-1024 µg/mL and the growth inhibition zone diameter of 4.3±0.3-18.2±0.1 mm. Conclusion: The antibacterial effect of the new banzothiazole derivatives was confirmed on S. iniae and E. tarda pathogens for the first time. M3 ER -