TY - JOUR T1 - Association of UCP3 (uncoupling protein 3) gene -55C/T polymorphism and obesity in a juvenile population of Iran TT - ارتباط پلی‌مورفیسم -55C/T ژن UCP3 (uncoupling protein 3) با چاقی در یک جمعیت ایرانی JF - JABS JO - JABS VL - 8 IS - 1 UR - http://jabs.fums.ac.ir/article-1-1089-en.html Y1 - 2018 SP - 594 EP - 600 KW - obesity KW - UCP3 gene KW - polymorphism KW - PCR-RFLP N2 - Background & Objective: UCP3 is a member of uncoupling proteins which plays an important role in energy homeostasis and it might be important in obesity. C-55T (rs1800849) polymorphism in promoter of UCP3 can affect the expression level of UCP3. The aim of this study was to analyze the association of UCP3 C-55T polymorphism and obesity in a juvenile population of Iran. Material & Methods: peripheral blood sample from 120 obese and 120 normal university students were collected for DNA extraction. Genotyping of C-55T polymorphism in the UCP3 gene was performed by PCR-RFLP method. Chi-square test was applied to analyze the data at P<0.05 significance level. Results: The variant T allele was significantly associated with the obesity risk. The frequency of T allele was 72% in Obese group compared to 40% in normal subjects (P= 0.000, OR=3.8 CI 95% 2.1 – 6.9). Conclusion: The UCP3 C-55T polymorphism was associated with higher BMI and can be regarded as a risk factor for the development of obesity. M3 ER -