%0 Journal Article %A Dashtiyan, Amin Allah %A Afzalpour, Mohammad Esmaeil %A Tanideh, Nader %A Sepehrimanesh, Masood %T The comparison of the effect of vitamin E on the expression of p53/PTEN of prostate gland of male rats in two groups of intensive continuous and intermittent exercise training %J Journal of Advanced Biomedical Sciences %V 7 %N 3 %U http://jabs.fums.ac.ir/article-1-1325-en.html %R %D 2017 %K Vitamin E, Continuous training, intermittent training, p53, PTEN, Prostate Gland, %X Background & Objective: Physical activity and diet are the most important modifiable determinants of cancer risk. The aim of this study was to investigate the comparison of the effect of vitamin E on the expression of p53/PTEN prostate gland of male rats in two groups of intensive continuous and intermittent exercise training. Materials & Methods: For this purpose, 56 male rats were randomly divided into 7 groups: [1] control group, [2] sham group, [3] intensive continuous training, [4] intensive intermittent training, [5] intensive continuous training + vitamin E, [6] intensive intermittent training + vitamin E, [7] vitamin E. The research training protocols were conducted in compliance with the principle of overload on the treadmill for six days a week, lasting 6 weeks. To measure expression changes of p53 and PTEN genes in rats' prostate, real-time PCR method was used and HPLC method was used to measure vitamin E. The One-way analysis of Variance test was used for comparisons among groups. Results: Vitamin E in combination with continuous training induced a significant decrease in the p53 gene expression of IIT + VE group (p > 0/004) compared to the control group. In contrast, vitamin E in combination with intermittent training induced a significant decrease in expression of p53 (p>0/013) and a significant increase in the PTEN gene expression (p>0/035). Conclusion: The results showed that physical exercise training reduced PTEN and p53 tumor suppressing gene expression by reducing oxidative stress, and vitamin E can be a somewhat increased expression of these genes. %> http://jabs.fums.ac.ir/article-1-1325-en.pdf %P 406-415 %& 406 %! Effect of Vitamin E and Aerobic Exercise on the Expression of p53 / PTEN genes %9 Research %L A-10-1483-1 %+ Department of Exercise Physiology, University of Birjand, Birjand, Iran %G eng %@ 2228-5105 %[ 2017