TY - JOUR T1 - The effect of Panax ginseng extract on histomorphometric changes on brachial plexus region of the spinal cord in 20 days fetuses of diabetic rats TT - اثر عصاره Panax ginseng بر تغییرات هیستومورفومتریک ناحیه شبکه بازویی نخاع در جنین‌های 20 روزه موش‌های صحرایی دیابتی JF - JABS JO - JABS VL - 8 IS - 2 UR - http://jabs.fums.ac.ir/article-1-1513-en.html Y1 - 2018 SP - 795 EP - 804 KW - Diabetes mellitus KW - brachial plexus region of spinal cord KW - Panax ginseng extract KW - Streptozotocin KW - Rat N2 - Background & Objective: Diabetes mellitus is a group of metabolic disorders characterized by increased levels of glucose. Ginseng has been used to control the diabetes for many years ago. This study investigated the effect of Panax ginseng extract on histomorphometric changes on brachial plexus region of spinal cord in 20 days fetuses of diabetic rats. Material & Methods: 16 rats were divided into four groups: non-diabetic control, non-diabetic recipient of the extract, diabetic control and diabetic recipient of the extract. Diabetes was induced by streptozotocin in diabetic groups and all groups became pregnant. During pregnancy, recipient of the extract groups received ginseng extract every day. On the 20th day of pregnancy, the mothers were anesthetized, and the fetuses were obtained. Brachial region of the spinal cord with vertebral column separated after using the techniques of histology, some histological factors were measured. Data were analyzed by using SPSS software and ANOVA and Duncan statistical tests (P≤0.05). Results: A significant difference was observed in the transverse and vertical diameter of central canal of the spinal cord in brachial plexus region of fetuses in diabetic control group than non-diabetic groups (P≤0.05). A significant reduction was observed in height of ependymal cells and cell count of gray matter of spinal cord in diabetic control group than other groups (P≤0.05). Conclusion: Extract of Panax ginseng can control hyperglycemia and manage diabetes on spinal cord in fetuses of mothers with gestational diabetes by increasing β-cells stimulation and increasing insulin production. M3 ER -