RT - Journal Article T1 - The Effect of Endurance Training and L-Carnitine Consumption on TNF-a and IL-1β Gene Expression of Heart Tissue in Wistar Male Rats following Anabolic Steroid Consumption (Boldenone) JF - JABS YR - 2019 JO - JABS VO - 9 IS - 4 UR - http://jabs.fums.ac.ir/article-1-1911-en.html SP - 1903 EP - 1912 K1 - Aerobic training K1 - Boldenone K1 - L-carnitine K1 - TNF-α K1 - IL-1β AB - Background & Objective: The aim of this study was to investigate the effect of endurance training and L-carnitine consumption on TNF-a and IL-1β gene expression of heart tissue in Wistar male rats following anabolic steroid consumption (Boldenone). Materials & Methods: In this experimental study, 30 male Wistar rats aged 12 weeks (weight 195±7.94g) were randomly divided into five groups including control, no-treatment, boldenone (5mg/kg), L-carnitine and aerobic training- L-carnitine. The endurance moderate intensity training program (55-50% of maximal oxygen consumption) was performed for 6 weeks and 5 times a week. Injection was conducted once a week, on an appointed day, and in the quadriceps and hamstring it was conducted in depth. After anesthesia, autopsy was performed and the heart was isolated. The TNF-α and IL-1β gene expression in the samples was measured by Real Time PCR. Data were analyzed using t-test, One-way ANOVA and post hoc Scheffe at the significant level of P<0.05. Results: The results showed that there was a significant difference between the mean TNF-α and IL-1β gene expression of heart tissue in male Wistar rats in different groups (P=0.001). The changes in TNF-α and IL-1β gene expression of heart tissue in L-carnitine and Training-L-carnitine groups were significantly lower than those of the no-treatment and boldenon groups (P=0.001). Conclusion: It seems that supplementation of L-carnitine with regular aerobic training reduces heart tissue damage induced by anabolic androgenic steroids. LA eng UL http://jabs.fums.ac.ir/article-1-1911-en.html M3 ER -