Journal of Advanced Biomedical Sciences
مجله علوم زیست پزشکی پیشرفته
JABS
Medical Sciences
http://jabs.fums.ac.ir
1
admin
2228-5105
2783-1523
8
7
14
8888
13
en
jalali
1399
12
1
gregorian
2021
3
1
11
1
online
1
fulltext
en
بررسی تاثیر عصاره و پودر برگ درخت توت سفید بر سطح سرمی نسفاتین-1 در رت های مبتلا به دیابت نوع 2 القا شده با Nicotinamide/Streptozotocin
Impact of Mulberry Leaf Extract and Mulberry Leaf Powder on Serum Nesfatin-1 Level in Nicotinamide/Streptozotocin-Induced Type 2 Diabetic Rats
بيوشيمي بالینی
Biochemistry
پژوهشي
Research
<div style="text-align: justify;"><div></div><div></div><strong><em>Background & Objective:</em></strong> In traditional medicine, leaves of white mulberry (Morus alba L.) are used as antidiabetic agents. Considering the presence of flavonoids, this plant exhibits insulin mimetic activities. Nesfatin-1 is described as an anorexigenic regulatory peptide, which can influence glucose metabolism via insulin sensitivity enhancement. This study examined the effects of both mulberry leaf powder and extract (MLP and MLE) on fasting blood glucose (FBG), nesfatin-1, and insulin in diabetic Wistar rats.<br>
<strong><em>Materials & Methods: </em></strong>Five groups of rats (n, 40) were included and examined in this study. A group was selected as the healthy control (I), while the other groups received streptozotocin and nicotinamide (55 and 110 mg/kg bw, respectively) for diabetes induction. Diabetic rats were then grouped as follows: control group (II); sham group (receiving ethanol) (III); treatment group receiving 600 mg/kg/day of MLE (IV); and treatment group receiving 25% MLP (V). After 6 weeks, we measured insulin, nesfatin-1, and FBG in the groups. <br>
<strong><em>Results:</em></strong> The FBG level decreased in the treatment groups, while serum insulin increased in comparison with the diabetic controls. In addition, serum level of nesfatin-1 improved significantly (to an almost normal level) in MLP rats in comparison with the diabetic controls. (pvalue<0.05) The effects of MLE on serum nesfatin-1 was similar to MLP but not significant. (pvalue>0.05)<br>
<strong><em>Conclusion:</em></strong> Considering the reduction in insulin level and the rise in blood glucose, the diabetic control group showed an increase in serum nesfatin-1 with a compensatory mechanism, while hyperglycemia improved in the MLE and MLP groups, and the level of nesfatin-1 reduced. MLP showed greater efficacy than MLE in the improvement of nesfatin-1, which might be related to the presence of ethanol in MLE.<br>
</div>
Nesfatin-1, Type 2 diabetes, Mulberry Leaf, Rat
3667
3673
http://jabs.fums.ac.ir/browse.php?a_code=A-10-2252-2&slc_lang=en&sid=1
Maryam
Eskandari Mehrabadi
مریم
اسکندری مهرآبادی
m92eskandari@gmail.com
100319475328460025346
100319475328460025346
No
Students Research Committee, Arak University of Medical Sciences, Arak, Iran
کمیته تحقیقات دانشجویی، دانشگاه علوم پزشکی اراک، اراک، ایران
zahra
salemi
زهرا
سالمی
Zahra Salemi
100319475328460025347
100319475328460025347
Yes
Department of Biochemistry, Arak University of Medical Sciences, Arak, Iran
گروه بیوشیمی، دانشگاه علوم پزشکی اراک، اراک، ایران
Soudabeh
Fallah
سودابه
فلاح
Soudabeh_Fallah@gmail.com
100319475328460025348
100319475328460025348
No
Department of Biochemistry, Arak University of Medical Sciences, Arak, Iran
گروه بیوشیمی، دانشگاه علوم پزشکی اراک، اراک، ایران