Journal of Advanced Biomedical Sciences
مجله علوم زیست پزشکی پیشرفته
JABS
Medical Sciences
http://jabs.fums.ac.ir
1
admin
2228-5105
2783-1523
8
7
14
8888
13
en
jalali
1399
8
1
gregorian
2020
11
1
10
4
online
1
fulltext
fa
مطالعه اثر محافظتی کوآنزیم Q10 بر لقاح داخل آزمایشگاهی و شاخصهای استرس اکسیداتیو در موش سوری تحت تیمار با نانوذرّات نقره
Study of the Protective Effect of Coenzyme Q10 on in Vitro Fertilization and Oxidative Stress Characteristics in Mice Treated with Silver Nanoparticles
جنين شناسي
Embryology
پژوهشي
Research
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<strong><em>Background & Objectives:</em></strong> Coenzyme Q<sub>10</sub> has potent antioxidant properties and is involved in the redox cycle as an energy carrier. Silver nanoparticles increase the potential hazards on the reproductive system by producing reactive oxygen species and reduce sperm quality and fertility. The aim of this study was to investigate the effects of silver nanoparticles on in vitro fertilizing potential and oxidative stress indices in mice.</pre>
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<strong><em>Materials & Methods:</em></strong> In this study, 20 adult male mice were divided into 5 control and experimental groups. The control group did not receive any substances. In the experimental groups, silver nanoparticles were fed at doses of 50 and 100 mg/kg. In one group, coenzyme Q<sub>10</sub> was given at a dose of 200 mg/kg alone. In the last group, the animals received silver nanoparticles + coenzyme Q<sub>10</sub> together. After the treatment period, the mice were euthanized. For testosterone investigation, blood sampling and then for IVF evaluation, sperms from the tail of the epididymis were taken. Testicular tissue was sampled to assess TAC, and MDA and were analyzed by one-way ANOVA and then Tukey test (p<0.05).</pre>
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<strong><em>Results:</em></strong> IVF results showed that the quality of the fetus and its growth stages in the experimental groups were significantly diminished compared to the control group (p<0.05). Also, malondialdehyde level and total antioxidant capacity in experimental groups increased and decreased significantly compared to the control group, respectively.<span dir="RTL"></span></pre>
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<strong><em>Conclusions:</em></strong> The present results exhibited that coenzyme Q<sub>10</sub> was able to improve the adverse effects of silver nanoparticles on the reproductive system, sperm quality, and fertility.<strong><span dir="RTL"></span></strong></pre>
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Silver nanoparticles, IVF, Embryologic development, Oxidative stress, Coenzyme Q10
2758
2767
http://jabs.fums.ac.ir/browse.php?a_code=A-10-2520-3&slc_lang=fa&sid=1
Ramin
Jahangirfard
رامین
جهانگیرفرد
r.jahangirfard@urmia.ac.ir
5040067321
100319475328460023904
Yes
Department of Comparative Anatomy and Embryology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
گروه آناتومی و جنینشناسی مقایسهای، دانشکده دامپزشکی، دانشگاه ارومیه، ارومیه، ایران