Journal of Advanced Biomedical Sciences
مجله علوم زیست پزشکی پیشرفته
JABS
Medical Sciences
http://jabs.fums.ac.ir
1
admin
2228-5105
2783-1523
8
7
14
8888
13
en
jalali
1400
6
1
gregorian
2021
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online
1
fulltext
en
اثر تعدیل کننده تروگزروتین بر آپلین -13 و بیان ژن گیرنده آن در تخمدان موشهای باردار تغذیه شده با رژیم غذایی پرچرب
The Effect of Troxerutin on Apelin-13 and Its Receptor Gene Expression in Ovarian of Pregnant Rats Fed a High-fat diet
فيزيولوژي
Physiology
پژوهشي
Research
<div style="text-align: justify;"><strong><em>Background & Objective:</em></strong> Apelin is a newly discovered member of adipocytokines that acts as an endogenous ligand for the G-coupled receptor for the protein orphan (APJ). This study aimed at investigating the beneficial effect of troxerutin (TRO) on apelin-13 and its receptor mRNA expression in the ovary of high-fat diet (HFD) fed rats.<br>
<strong><em>Materials & Methods:</em></strong> 40 three-week old female Wistar rats received control diet (CD) or HFD for 8 weeks. After mating, pregnant animals were divided into 4 subgroups: CD, CD +TRO, HFD, and HFD + TRO. Respective diets continued to the end of lactation. CD +TRO and HFD +TRO groups received troxerutin (150 mg/kg/day, P.O.) during pregnancy. After weaning offspring, animals in the maternal group were sacrificed. Then blood samples and ovarian tissue samples were collected for further evaluation.<br>
<strong><em>Results:</em></strong> The results indicated that HFD significantly increased serum apelin-13 in HFD dams, which was reversed by TRO treatment. Also, analysis showed that ovarian mRNA expression of the apelin receptor markedly down-regulated in the HFD group compared to control groups. It was also revealed that treatment with troxerutin in the HFD group could significantly increase apelin receptor mRNA expression in comparison with the both CD and HFD groups.<br>
<strong><em>Conclusion:</em></strong> Troxerutin treatment in obese pregnant mothers can affect the function of the reproductive system by modulating the serum apelin 13 and the expression of its receptor gene.<br>
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Apelin-13, APJ receptor, Maternal high-fat diet, Troxerutin
3958
3966
http://jabs.fums.ac.ir/browse.php?a_code=A-10-2873-1&slc_lang=en&sid=1
Keyvan
Mehri
کیوان
مهری
keivanm20@gmail.com
100319475328460026404
100319475328460026404
No
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
مرکز تحقیقات کاربردی دارویی، دانشگاه علوم پزشکی تبریز، تبریز، ایران
Shirin
Babri
شیرین
ببری
shirinb46@yahoo.com
100319475328460026405
100319475328460026405
Yes
Department of Physiology, Tabriz University of Medical Sciences, Tabriz, Iran
گروه فیزیولوژی، دانشگاه علوم پزشکی تبریز، تبریز، ایران