Journal of Advanced Biomedical Sciences
مجله علوم زیست پزشکی پیشرفته
JABS
Medical Sciences
http://jabs.fums.ac.ir
1
admin
2228-5105
2783-1523
8
7
14
8888
13
en
jalali
1393
8
1
gregorian
2014
11
1
4
3
online
1
fulltext
fa
مقایسه اثر عسل طبیعی و متفورمین بر هیستوپاتولوژی پانکراس موشهای صحرائی مبتلا شده به دیابت با استرپتوزوتوسین
Comparison of Natural Honey and Metformin on Pancreatic Histopathology in STZ- Induced Diabetic Rats
فيزيولوژي
Physiology
پژوهشي
Research
<p style="direction: rtl"><a name="OLE_LINK30"><b><span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">زمینه
و هدف</span></b></a><span style="mso-bookmark: OLE_LINK30"><span dir="ltr"></span><span dir="ltr"></span><b><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>: </span></b></span><span style="mso-bookmark: OLE_LINK30"><span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">استفاده از آنتی اکسیدانهای طبیعی رویکرد جدیدی در کنترل
بیماری دیابت است. در این مطالعه اثر عسل طبیعی (به عنوان یک آنتیاکسیدان قوی) با
داروی متفورمین (یک داروی متداول برای بیماران دیابتی) بر تغییرات بافتی پانکراس
در موشهای صحرائی مبتلا به دیابت مقایسه گردید</span></span><span style="mso-bookmark: OLE_LINK30"><span dir="ltr"></span><span dir="ltr"></span><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>.</span></span></p><p class="MsoNormal" style="margin: 0cm 0cm 10pt text-align: justify line-height: normal unicode-bidi: embed direction: rtl" dir="rtl"><span style="mso-bookmark: OLE_LINK30"><b><span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">مواد و روش</span></b></span><span style="mso-bookmark: OLE_LINK30"><b><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-font-size: 10.0pt" dir="ltr"></span></b></span><span style="mso-bookmark: OLE_LINK30"><b><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"></span></b></span><span style="mso-bookmark: OLE_LINK30"><b><span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">ها</span></b></span><span style="mso-bookmark: OLE_LINK30"><span dir="ltr"></span><span dir="ltr"></span><b><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>: </span></b></span><span style="mso-bookmark: OLE_LINK30"><span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">سی موش</span></span><span style="mso-bookmark: OLE_LINK30"><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span></span><span style="mso-bookmark: OLE_LINK30"><span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">صحرائی نر در محدودهی وزنی 220-180 گرم به
صورت تصادفی به شش گروه تقسیم شدند؛</span></span><span style="mso-bookmark: OLE_LINK30"><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span></span><span style="mso-bookmark: OLE_LINK30"><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-font-size: 10.0pt" dir="ltr">:C</span></span><span style="mso-bookmark: OLE_LINK30"><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"> </span></span><span style="mso-bookmark: OLE_LINK30"><span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">رتهای
سالم دریافتکننده آب مقطر</span></span><span style="mso-bookmark: OLE_LINK30"><span dir="ltr"></span><span dir="ltr"></span><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> (</span></span><span style="mso-bookmark: OLE_LINK30"><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-font-size: 10.0pt" dir="ltr">ml</span></span><span style="mso-bookmark: OLE_LINK30"><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"> 5/0)</span></span><span style="mso-bookmark: OLE_LINK30"><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA"><span dir="rtl"></span><span dir="rtl"></span>،</span></span><span style="mso-bookmark: OLE_LINK30"><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span></span><span style="mso-bookmark: OLE_LINK30"><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-font-size: 10.0pt" dir="ltr">:CH</span></span><span style="mso-bookmark: OLE_LINK30"><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"> </span></span><span style="mso-bookmark: OLE_LINK30"><span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">سالم دریافت کننده عسل</span></span><span style="mso-bookmark: OLE_LINK30"><span dir="ltr"></span><span dir="ltr"></span><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> (</span></span><span style="mso-bookmark: OLE_LINK30"><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-font-size: 10.0pt" dir="ltr">g/kg b.w 1</span></span><span style="mso-bookmark: OLE_LINK30"><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr">)</span></span><span style="mso-bookmark: OLE_LINK30"><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA"><span dir="rtl"></span><span dir="rtl"></span>،</span></span><span style="mso-bookmark: OLE_LINK30"><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span></span><span style="mso-bookmark: OLE_LINK30"><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-font-size: 10.0pt" dir="ltr">:DC</span></span><span style="mso-bookmark: OLE_LINK30"><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"> </span></span><span style="mso-bookmark: OLE_LINK30"><span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">دیابتی دریافتکننده آب مقطر</span></span><span style="mso-bookmark: OLE_LINK30"><span dir="ltr"></span><span dir="ltr"></span><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> (</span></span><span style="mso-bookmark: OLE_LINK30"><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-font-size: 10.0pt" dir="ltr">ml</span></span><span style="mso-bookmark: OLE_LINK30"><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"> 5/0)</span></span><span style="mso-bookmark: OLE_LINK30"><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA"><span dir="rtl"></span><span dir="rtl"></span>،</span></span><span style="mso-bookmark: OLE_LINK30"><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span></span><span style="mso-bookmark: OLE_LINK30"><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-font-size: 10.0pt" dir="ltr">:DH</span></span><span style="mso-bookmark: OLE_LINK30"><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"> </span></span><span style="mso-bookmark: OLE_LINK30"><span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">دیابتی تحت تیمار عسل طبیعی</span></span><span style="mso-bookmark: OLE_LINK30"><span dir="ltr"></span><span dir="ltr"></span><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> (</span></span><span style="mso-bookmark: OLE_LINK30"><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-font-size: 10.0pt" dir="ltr">g/kgb.w1</span></span><span style="mso-bookmark: OLE_LINK30"><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr">)</span></span><span style="mso-bookmark: OLE_LINK30"><span dir="rtl"></span><span dir="rtl"></span><span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA"><span dir="rtl"></span><span dir="rtl"></span>،</span></span><span style="mso-bookmark: OLE_LINK30"><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span></span><span style="mso-bookmark: OLE_LINK30"><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-font-size: 10.0pt" dir="ltr">:DM</span></span><span style="mso-bookmark: OLE_LINK30"><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"> </span></span><span style="mso-bookmark: OLE_LINK30"><span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">دیابتی تحت تیمار متفورمین</span></span><span style="mso-bookmark: OLE_LINK30"><span dir="ltr"></span><span dir="ltr"></span><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> (</span></span><span style="mso-bookmark: OLE_LINK30"><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-font-size: 10.0pt" dir="ltr">mg/kg</span></span><span style="mso-bookmark: OLE_LINK30"><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr">100) </span></span><span style="mso-bookmark: OLE_LINK30"><span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">و</span></span><span style="mso-bookmark: OLE_LINK30"><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span></span><span style="mso-bookmark: OLE_LINK30"><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-font-size: 10.0pt" dir="ltr">:DMH</span></span><span style="mso-bookmark: OLE_LINK30"><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"> </span></span><span style="mso-bookmark: OLE_LINK30"><span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">دیابتی تیمار شده با عسل و متفورمین. دیابت با تزریق
استرپتوزوتوسین</span></span><span style="mso-bookmark: OLE_LINK30"><span dir="ltr"></span><span dir="ltr"></span><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> (</span></span><span style="mso-bookmark: OLE_LINK30"><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-font-size: 10.0pt" dir="ltr">STZ</span></span><span style="mso-bookmark: OLE_LINK30"><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr">) </span></span><span style="mso-bookmark: OLE_LINK30"><span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">به
میزان</span></span><span style="mso-bookmark: OLE_LINK30"><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span></span><span style="mso-bookmark: OLE_LINK30"><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-font-size: 10.0pt" dir="ltr">mg/kg, i.p</span></span><span style="mso-bookmark: OLE_LINK30"><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"> 65 </span></span><span style="mso-bookmark: OLE_LINK30"><span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">القاء
شد.حیوانات به مدت یک ماه به طور روزانه گاواژ شدند. پس از پایان دوره درمان،
پانکراس حیوانات خارج گردید و پس از طی مراحل تثبیت، آمادهسازی و رنگآمیزی به
روش</span></span><span style="mso-bookmark: OLE_LINK30"><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span></span><span style="mso-bookmark: OLE_LINK30"><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-font-size: 10.0pt" dir="ltr">H&E</span></span><span style="mso-bookmark: OLE_LINK30"><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"> </span></span><span style="mso-bookmark: OLE_LINK30"><span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">مورد
مطالعه قرار گرفتند</span></span><span style="mso-bookmark: OLE_LINK30"><span dir="ltr"></span><span dir="ltr"></span><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>.</span></span></p><p class="MsoNormal" style="margin: 0cm 0cm 10pt text-align: justify line-height: normal unicode-bidi: embed direction: rtl" dir="rtl"><span style="mso-bookmark: OLE_LINK30"><b><span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">نتایج</span></b></span><span style="mso-bookmark: OLE_LINK30"><span dir="ltr"></span><span dir="ltr"></span><b><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>:</span></b></span><span style="mso-bookmark: OLE_LINK30"><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"> </span></span><span style="mso-bookmark: OLE_LINK30"><span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">دیابت
باعث کاهش معنی داری</span></span><span style="mso-bookmark: OLE_LINK30"><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span></span><span style="mso-bookmark: OLE_LINK30"><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-font-size: 10.0pt" dir="ltr">(001/0P<)</span></span><span style="mso-bookmark: OLE_LINK30"><span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">در قطر جزایر و تعداد جزایر لانگرهانس در گروه
کنترل دیابت نسبت به گروههای کنترل گردید. قطر جزایر در گروه</span></span><span style="mso-bookmark: OLE_LINK30"><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span></span><span style="mso-bookmark: OLE_LINK30"><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-font-size: 10.0pt" dir="ltr">DMH</span></span><span style="mso-bookmark: OLE_LINK30"><span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">نسبت
به گروه</span></span><span style="mso-bookmark: OLE_LINK30"><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span></span><span style="mso-bookmark: OLE_LINK30"><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-font-size: 10.0pt" dir="ltr">DH</span></span><span style="mso-bookmark: OLE_LINK30"><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"> </span></span><span style="mso-bookmark: OLE_LINK30"><span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">و
گروه</span></span><span style="mso-bookmark: OLE_LINK30"><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span></span><span style="mso-bookmark: OLE_LINK30"><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-font-size: 10.0pt" dir="ltr">DM</span></span><span style="mso-bookmark: OLE_LINK30"><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"> </span></span><span style="mso-bookmark: OLE_LINK30"><span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">به
تنهایی افزایش معنیداری</span></span><span style="mso-bookmark: OLE_LINK30"><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span></span><span style="mso-bookmark: OLE_LINK30"><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-font-size: 10.0pt" dir="ltr">(05/0P<)</span></span><span style="mso-bookmark: OLE_LINK30"><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"> </span></span><span style="mso-bookmark: OLE_LINK30"><span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">نشان
داد. همچنین آثار آتروفی جزایر و تخریب هسته در گروه</span></span><span style="mso-bookmark: OLE_LINK30"><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span></span><span style="mso-bookmark: OLE_LINK30"><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-font-size: 10.0pt" dir="ltr">DC</span></span><span style="mso-bookmark: OLE_LINK30"><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"> </span></span><span style="mso-bookmark: OLE_LINK30"><span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">مشهود بود و در گروههای تحت تیمار شاهد بهبودی این عوارض
بودیم</span></span><span style="mso-bookmark: OLE_LINK30"><span dir="ltr"></span><span dir="ltr"></span><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>.</span></span></p><p class="MsoNormal" style="margin: 0cm 0cm 10pt text-align: justify line-height: normal unicode-bidi: embed direction: rtl" dir="rtl"><span style="mso-bookmark: OLE_LINK30"><b><span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">نتیجهگیری</span></b></span><span style="mso-bookmark: OLE_LINK30"><span dir="ltr"></span><span dir="ltr"></span><b><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>:</span></b></span><span style="mso-bookmark: OLE_LINK30"><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"> </span></span><span style="mso-bookmark: OLE_LINK30"><span lang="FA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt mso-bidi-language: FA">عسل
طبیعی میتواند اثرات ترمیمی بر بافت پانکراس در موشهای دیابتی داشته باشد.
همچنین</span></span><span style="mso-bookmark: OLE_LINK30"><span dir="ltr"></span><span dir="ltr"></span><span lang="FA" style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-language: FA mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span> </span></span><span style="mso-bookmark: OLE_LINK30"><span lang="AR-SA" style="color: black font-family: "B Nazanin" font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ascii-font-family: "Times New Roman" mso-hansi-font-family: "Times New Roman" mso-ansi-font-size: 8.0pt">کاربرد
متفورمین به همراه عسل طبیعی اثر بخشی دارو را در کنترل عوارض دیابت بهبود میبخشد
که احتمالا بدلیل دارا بودن خواص آنتی اکسیدانی عسل میباشد</span></span><span style="mso-bookmark: OLE_LINK30"><span dir="ltr"></span><span dir="ltr"></span><span style="color: black font-family: "Times New Roman",serif font-size: 8pt mso-fareast-font-family: "Times New Roman" mso-bidi-font-family: "B Nazanin" mso-bidi-font-size: 10.0pt" dir="ltr"><span dir="ltr"></span><span dir="ltr"></span>.</span></span></p><p class="MsoNormal" style="margin: 0cm 0cm 8pt"><span style="line-height: 107% font-family: "Times New Roman",serif font-size: 8pt mso-bidi-font-family: "B Nazanin" mso-bidi-font-size: 10.0pt"><!--stripped--><font size="2"> </font><!--stripped--></span></p>
<p><font face="Times New Roman" size="3"> </font><b><i><span style="color: black font-family: "Times New Roman",serif font-size: 10pt mso-fareast-font-family: "Times New Roman"">Background& Objective</span></i></b><i><span style="color: black font-family: "Times New Roman",serif font-size: 10pt mso-fareast-font-family: "Times New Roman"">:</span></i><span style="color: black font-family: "Times New Roman",serif font-size: 10pt mso-fareast-font-family: "Times New Roman""> The use of natural antioxidants is a new approach in controlling
diabetes. In this study, the effect of natural honey (a powerful antioxidant)
was compared with metformin (a prevalent drug used for diabetes) on
histological changes of pancreas in diabetic rats.</span></p><p class="MsoNormal" style="margin: 0cm 0cm 8pt text-align: justify line-height: normal"><b><i><span style="color: black font-family: "Times New Roman",serif font-size: 10pt mso-fareast-font-family: "Times New Roman"">Materials& Methods</span></i></b><i><span style="color: black font-family: "Times New Roman",serif font-size: 10pt mso-fareast-font-family: "Times New Roman"">:</span></i><span style="color: black font-family: "Times New Roman",serif font-size: 10pt mso-fareast-font-family: "Times New Roman""> 30 male rats, weighting 180-220 gram </span><span lang="EN-GB" style="color: black font-family: "Times New Roman",serif font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ansi-language: EN-GB">were randomly divided
into six groups including C: non diabetic rats receiving distilled water (0.5
ml), CH: non diabetic rats receiving honey (1g/kg b.w), </span><span style="color: black font-family: "Times New Roman",serif font-size: 10pt mso-fareast-font-family: "Times New Roman"">C</span><span lang="EN-GB" style="color: black font-family: "Times New Roman",serif font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ansi-language: EN-GB">D: diabetic rats administered with
distilled water (0.5 ml), D.H: honey treated diabetic rats (1g/kg b.w),</span><span lang="EN-GB" style="color: black font-family: "Times New Roman",serif font-size: 10pt mso-fareast-font-family: "Times New Roman""> </span><span style="color: black font-family: "Times New Roman",serif font-size: 10pt mso-fareast-font-family: "Times New Roman"">DM: Metformin administrated-diabetic rats (100
mg/kg), and DMH: Metformin + honey-co-treated diabetic animals.</span><span lang="EN-GB" style="color: black font-family: "Times New Roman",serif font-size: 10pt mso-fareast-font-family: "Times New Roman" mso-ansi-language: EN-GB">Diabetes
was induced by a single dose of Streptozotcin (65 mg/kg i.p). The animals were
treated by oral gavage daily for a month. </span><span style="color: black font-family: "Times New Roman",serif font-size: 10pt mso-fareast-font-family: "Times New Roman"">After treatment, the pancreatic tissues of the animals were
excised, prepared, and stained with H & E method.</span></p><p class="MsoNormal" style="margin: 0cm 0cm 8pt text-align: justify line-height: normal"><b><i><span style="color: black font-family: "Times New Roman",serif font-size: 10pt mso-fareast-font-family: "Times New Roman"">Results:</span></i></b><b><span style="color: black font-family: "Times New Roman",serif font-size: 10pt mso-fareast-font-family: "Times New Roman""> </span></b><span style="color: black font-family: "Times New Roman",serif font-size: 10pt mso-fareast-font-family: "Times New Roman"">The results showed that the diameter and the number of islands of
the pancreas in diabetic control rats have more significant decrease
(p<0.001) than non-diabetic control rats. Diameter of the islands in DMH
group had significant increase compared with DH and DM groups (p<0.05).
Moreover, atrophy and destruction of the islet cells and the nucleus were
observed in DC group. We faced improvement of these complications in treatment
groups.</span></p><p class="MsoNormal" style="margin: 0cm 0cm 8pt text-align: justify line-height: normal"><b><i><span style="color: black font-family: "Times New Roman",serif font-size: 10pt mso-fareast-font-family: "Times New Roman"">Conclusion:</span></i></b><b><span style="color: black font-family: "Times New Roman",serif font-size: 10pt mso-fareast-font-family: "Times New Roman""> </span></b><span style="color: black font-family: "Times New Roman",serif font-size: 10pt mso-fareast-font-family: "Times New Roman"">Natural honey can have healing effect on the pancreas tissue of
diabetic rats. Due to the antioxidant properties of honey, combination of honey
and metformin can have restorative effect on pancreatic tissue repair in
diabetic rats.</span></p>
آنتی اکسیدان, دیابت, عسل طبیعی, متفورمین
Antioxidant, Diabetes, Natural Honey, Metformin
335
343
http://jabs.fums.ac.ir/browse.php?a_code=A-10-273-1&slc_lang=fa&sid=1
Ozra
Nasrolahi
عذرا
نصراللهی
nasrolahio@yahoo.com
10031947532846005659
10031947532846005659
Yes
Department Of Biology, Faculty of science, Urmia University, Urmia, Iran
گروه زیست شناسی، دانشکده علوم، دانشگاه ارومیه، ارومیه، ایران.
Fereshte
Khaneshi
فرشته
خانشی
10031947532846005660
10031947532846005660
No
Department Of Biology, Faculty of science, Urmia University, Urmia, Iran
گروه زیست شناسی، دانشکده علوم، دانشگاه ارومیه، ارومیه، ایران.
Fatemeh
Rahmani
فاطمه
رحمانی
10031947532846005661
10031947532846005661
No
Department Of Biology, Faculty of science, Urmia University, Urmia, Iran
گروه زیست شناسی، دانشکده علوم، دانشگاه ارومیه، ارومیه، ایران.