Volume 6, Issue 3 (11-2016)                   JABS 2016, 6(3): 303-310 | Back to browse issues page

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Raayat Jahromi A, Tabatabaei Naeini A, Tanideh N, Banan P. The Effect of Propofol Anesthesia on Cutaneous Wound Healing in Rats. JABS 2016; 6 (3) :303-310
URL: http://jabs.fums.ac.ir/article-1-962-en.html
The Effect of Propofol Anesthesia on Cutaneous Wound Healing in Rats
Alireza Raayat Jahromi * 1, Abutorab Tabatabaei Naeini2 , Nader Tanideh3 , Pegah Banan4
1- Veterinary Surgery, Department of Clinical Studies, School of Veterinary Medicine, Shiraz University, Shiraz, Iran , raayat@shirazu.ac.ir
2- Veterinary Surgery, Department of Clinical Studies, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
3- Transgenic Technology Research Center, Pharmacology Department, Shiraz University of Medical Sciences, Shiraz, Iran
4- Veterinary Medicine, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
Abstract:   (8309 Views)

Background & Objective: The present study surveys the effects of propofol on cutaneous wound healing in rats.

Materials & Methods: 36 adult female Strague-Dawely rats were divided into three groups randomly; in group one propofol (60 mg/kg) and ketamine (40 mg/kg) combination; in group two ketamine (50 mg/kg), and in group three propofol (100 mg/kg) was injected intraperitoneally. Following routine surgical preparation, 1.5×1.5 cm wounds were created on the back of the rats. Wound size was evaluated daily and then the wound area was calculated by Digimizer software. Following euthanasia on day 21 after wounding, 1×1 cm skin samples were collected for histopathological evaluations and hydroxyproline content.

Results: Wound size and hydroxyproline content showed no significant difference in propofol group compared to ketamine and propofol-ketamine groups. Fibroblast content and vascularity revealed no significant difference between groups. Inflammatory cell infiltration in ketamine group, collagen deposition in ketamine-propofol groups, and epithelial regeneration in propofol group were significantly higher in comparison with others.

Conclusion: In conclusion, single use of propofol has no adverse effect on cutaneous wound healing in rats compared to ketamine, but evaluation of its positive effects on wound healing necessitates more detailed studies.

Keywords: Propofol anesthesia, Cutaneous wound, Rat
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Type of Study: Research | Subject: General Surgery
Received: 2015/11/22 | Accepted: 2016/06/15 | Published: 2016/11/22
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