[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Submit :: Contact Us ::
:: Volume 9, Issue 1 (Spring 2019) ::
J Fasa Univ Med Sci 2019, 9(1): 1177-1186 Back to browse issues page
Types of glioma brain tumors and genetic alterations in signaling pathways in them
Narges Ahani1 , Mohammad Hossein Sangtarash 2, Massoud Houshmand3 , Majid Alipour eskandani4
1- Department of Biology, Faculty of sciences, University of Sistan and Baluchestan, Zahedan, Iran
2- Department of Biology, Faculty of sciences, University of Sistan and Baluchestan, Zahedan, Iran , sangtarash@science.usb.ac.ir
3- Department of Medical Genetics, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran
4- Department of Food Hygiene and Quality Control, Faculty of Veterinary Medicine, University of Zabol, Zabol, Iran
Abstract:   (809 Views)
Types of glioma brain tumors and genetic alterations in signaling pathways in them
Background & Objective: Glioma is a common type of primary brain tumor originating in the glial cells that surrounds and supports neurons in the brain. These tumors arise from three different types of cells that are normally found in the brain: astrocytes, oligodendrocytes, and ependymal cells, accordingly types of glioma include: Astrocytomas, Ependymomas, and Oligoastrocytomas. The signaling pathway has been described in systems biology terms as a complex biological network of three steps: (1) an input step in which membrane receptors and their ligands trigger the signal coming from outside the cell; (2) a core system processing step in which protein kinases transmit the signal to the nucleus; (3) an output step in which transcription factors regulate genes that affect various cellular functions.
Conclusion: Glioma characteristics are derived from the activation of these pathways, including uncontrolled proliferation, invasion, and angiogenesis. Understanding the genetic alterations that has occurred in these three steps, leading to the formation and progression of glioma tumors, may help improve patient prognosis in order to identify novel treatment targets. In this review, we provide an overview of the most recent developments and current understanding of genetic alterations in these signaling pathways in glioma.
 

 
Keywords: glioma, grade, signaling pathway.
Full-Text [PDF 1150 kb]   (563 Downloads)    
Type of Study: Review | Subject: Medical Genetics
Received: 2018/07/28 | Accepted: 2019/01/29 | Published: 2019/06/8
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

ahani N, Sangtarash M H, Houshmand M, alipour eskandani M. Types of glioma brain tumors and genetic alterations in signaling pathways in them . J Fasa Univ Med Sci. 2019; 9 (1) :1177-1186
URL: http://journal.fums.ac.ir/article-1-1574-en.html


Volume 9, Issue 1 (Spring 2019) Back to browse issues page
Journal of Fasa University of Medical Sciences
Persian site map - English site map - Created in 0.05 seconds with 31 queries by YEKTAWEB 3977