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:: Volume 8, Issue 4 (Winter 2019) ::
J Fasa Univ Med Sci 2019, 8(4): 1167-1176 Back to browse issues page
Effect of One Session of Resistance Exercises on Expression of BDNF Gene and TrkB Receptor in Alzheimer Model Male Wistar Rats
Gholamhasan Jafarzadeh1 , Saeid Shakeryan 2, Yaghoob Farbood3 , Mohsen Ghanbarzadeh1
1- Department of Sport Physiology, Faculty of Sport Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran
2- Department of Sport Physiology, Faculty of Sport Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran , sashakeryan@gmail.com
3- Department of Physiology, Faculty of Medicine, Khalij Fars Physiology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Abstract:   (1671 Views)
Background & Objective: This study is intended to evaluate the effect of One Session of resistance exercises on expression of BDNF gene and TrkB receptor in Alzheimer model male Wistar rats.
 Materials & Methods: 32 mature male Wistar rats with mean weight of 230 to 280 grams were chosen and divided into Alzheimer and Sham groups. Rats in Sham group received normal saline while rats in Alzheimer group received STZ via intraventricular injection. These rats were then divided into the following four subgroups: 1. Resting Sham, 2. Exercising Sham, 3. Resting Alzheimer, and 4. Exercising Alzheimer. The two exercising rat subgroups, exercised 3 times a week for a period of 8 weeks. Exercise included lifting weight from the ladder. At the end of 8th week and 24 hours after last exercise session, the rats scarified by head separation. Hippocampus tissue was precisely extracted and samples were sent to laboratory for molecular and cellular tests. To determine the gene expression, RT-PCR method was used for analyzing the data and ANOVA was used.
Results: The amount of BDNF, and TrkB between exercising rats and resting rats. These amounts were much higher in exercising Alzheimer rats group.
Conclusion: It seems that eight weeks of resistance exercises increased expression of BDNF gene and TrkA an TrkB receptor in Alzheimer model Wistar rats.
Keywords: Alzheimer, BDNF, Gene Expression, TrkB Receptor, Resistance Exercises, Rat
Full-Text [PDF 1039 kb]   (301 Downloads)    
Type of Study: Research | Subject: Physiology
Received: 2018/09/24 | Accepted: 2018/12/10 | Published: 2019/03/17
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Jafarzadeh G, Shakeryan S, Farbood Y, Ghanbarzadeh M. Effect of One Session of Resistance Exercises on Expression of BDNF Gene and TrkB Receptor in Alzheimer Model Male Wistar Rats . J Fasa Univ Med Sci. 2019; 8 (4) :1167-1176
URL: http://journal.fums.ac.ir/article-1-1836-en.html


Volume 8, Issue 4 (Winter 2019) Back to browse issues page
Journal of Fasa University of Medical Sciences
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