Volume 6, Issue 3 (11-2016)                   JABS 2016, 6(3): 389-398 | Back to browse issues page

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Hoseini S A, Zar A, Hoseini S A, Hassanpour G, Kheirdeh M, Noura M. Effect of Eight Weeks Forced Swimming Training with Methadone Supplementation on Aspartate Aminotransferase, Alanine Aminotransferase, and Alkaline Phosphatase of Rats. JABS 2016; 6 (3) :389-398
URL: http://jabs.fums.ac.ir/article-1-1043-en.html
Effect of Eight Weeks Forced Swimming Training with Methadone Supplementation on Aspartate Aminotransferase, Alanine Aminotransferase, and Alkaline Phosphatase of Rats
Seyed Ali Hoseini * 1, Abdosaleh Zar2 , Seyed Ali Hoseini3 , Ghobad Hassanpour3 , Maryam Kheirdeh4 , Mehdi Noura5
1- Sport Physiology Department, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran , alihoseini_57@miau.ac.ir
2- Sport Physiology Department, University of Jahrom, Jahrom, Iran
3- Sport Physiology Department, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran
4- Physical Education Department of Sama Collage, Shiraz Branch, Islamic Azad University, Shiraz, Iran
5- Sport Physiology Department, Shiraz Branch, Islamic Azad University, Shiraz, Iran
Abstract:   (8736 Views)

Background & Objective: Narcotics abuse can induce liver disorders; nevertheless, exercises improve liver disorders. The present research aimed to review the effect of eight weeks forced swimming training with methadone supplementation on liver enzymes of rats.

Material & Method: In this experimental research, 48 rats were selected, and after one week adaptation to lab environment, they were randomly divided into four groups of 12 rats including (1) forced swimming training, (2) methadone supplementation, (3) forced swimming training with methadone supplementation, and (4) control. Groups 2 and 3 used 2 mg/kg methadone daily for 8 weeks. Also, groups 1 and 3 swam for 8 weeks, three sessions per week and each session for 30 minutes. For statistical analysis of data, one way ANOVA and Tukey post hoc tests were used (α≤0.05).

Results: Findings showed that forced swimming training, methadone supplementation, and forced swimming training with methadone supplementation had no significant effect on AST (P=0.90) and ALT (P=0.99) enzymes; forced swimming training had significant effect on increase of ALP (P=0.001); also, forced swimming training, compared with methadone supplementation and combination of forced swimming training with methadone supplementation, had significant effect on increase of ALP (P=0.001).

Conclusion: Accordingly, 8 weeks of forced swimming training with methadone has possibly no significant effect on liver enzymes.

Keywords: Forced Swimming Training, Aspartate Aminotransferase, Alanine aminotransferase, Alkaline Phosphatase, Methadone
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Type of Study: Research | Subject: Physical Medicine and Rehabilitation
Received: 2016/02/26 | Accepted: 2016/09/5 | Published: 2016/12/4
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